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  1. Scholars Hub of the Academia Sinica

Browsing "生命科學組" by Author brik, a.


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Showing results 1 to 20 of 20
Issue DateTitleAuthor(s)RelationscopusWOSFulltext/Archive link
20051,2,3-triazole as a peptide surrogate in the rapid synthesis of HIV-1 protease inhibitorsBrik, A.; Alexandratos, J.; Lin, Y. C.; Elder, J. H.; Olson, A. J.; Wlodawer, A.; Goodsell, D. S.; Wong, C. H.Chembiochem 6, 1167-1169
2008A copper(I)-catalyzed 1,2,3-triazole azide-alkyne click compound is a potent inhibitor of a multidrug-resistant HIV-1 protease variantGiffin, M. J.; Heaslet, H.; Brik, A.; Lin, Y. -C.; Cauvi, G.; Wong, C. -H.; McRee, D. E.; Elder, J. H.; Stout, C. D.; Torbett, B. E.J. Med. Chem 51(20), 6263-6270
2002A quick diversity-oriented amide-forming reaction to optimize P-subsite residues of HIV protease inhibitorsBrik, A.; Lin, Y. C.; Elder, J.; Wong, C. H.Chem Biol 9, 891-896
2003Design and synthesis of broad-based mono- and bi- cyclic inhibitors of FIV and HIV proteasesMak, C. C.; Brik, A.; Lerner, D. L.; Elder, J. H.; Morris, G. M.; Olson, A. J.; Wong, C. H.BIOORGANIC & MEDICINAL CHEMISTRY 11, 2025-2040
2006Epoxide opening in water and screening in situ for rapid discovery of enzyme inhibitors in microtiter platesLiang, F. S.; Brik, A.; Lin, Y. C.; Elder, J. H.; Wong, C. H.Bioorganic & medicinal chemistry 14, 1058-1062
2007Extended Sugar-Assisted Ligations: Development, Scope and ApplicationsPayne, R. J.; Ficht, S.; Tang, S.; Brik, A.; Yang, Y. -Y.; Case, D. A.; Wong, C. -H.J. Am. Chem. Soc 129(44), 13527-13536
2003HIV-1 protease: mechanism and drug discoveryBrik, A.; Wong, C. H.Org Biomol Chem 1, 5-14
2006Microtiter Plate Based Chemistry and In Situ Screening: A Useful Approach for Rapid Inhibitors DiscoveryBrik, A.; Wu, C. Y.; Wong, C. H.ORGANIC & BIOMOLECULAR CHEMISTRY 4, 1446-1457
2004Model system for high-throughput screening of novel human immunodeficiency virus protease inhibitos in Escherichia coliCheng, T. J.; Brik, A.; Wong, C. H.; Kan, C. C.Antimicrob Agents Chemother 48, 2437-2447
2004Rapid Discovery of Potent Sulfotransferase Inhibitors by Diversity-Oriented Reaction in Microplates Followed by in situ ScreeningBest, M. D.; Brik, A.; Chapman, E.; Lee, L. V.; Cheng, W. C.; Wong, C. H.Chembiochem 5, 811-819
2003Rapid diversity-oriented synthesis in microtiter plates for in situ screening of HIV protease inhibitorsBrik, A.; Muldoon, J.; Lin, Y. C.; Elder, J. H.; Goodsell, D. S.; Olson, A. J.; Fokin, V. V.; Sharpless, K. B.; Wong, C. H.Chembiochem 4, 1246-1248
2007Second Generation Sugar-Assisted Ligation: An Effective New Method for the Synthesis of Cysteine-Containing GlycopeptidesFicht, S.; Payne, R. J.; Brik, A.; Wong, C. H.Angewandte chemie-international edition 46(31), 5975-5979
2004Small molecules targeting severe acute respiratory syndrome human coronavirusWu, C. Y.; Jan, J. T. ; Ma, S. H.; Kuo, C. J.; Juan, H. F.; Cheng, Y. S.; Hsu, H. H.; Huang, H. C.; Wu, D.; Brik, A.; Liang, F. S.; Liu, R. S.; Fang, J. M.; Chen, S. T. ; Liang, P. H. ; Wong, C. H. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101(27), 10012-10017
2006Strategies for the Preparation of Homogenous GlycoproteinsBrik, A.; Ficht, S.; Wong, C. -H.CURRENT OPINION IN CHEMICAL BIOLOGY 10(6):638-644.
2008Sugar-assisted Glycopeptide Ligation with Complex Oligosaccharides: Scope and LimitationsBennett, C.; Dean, S.; Payne, R.; Ficht, S.; Brik, A.; Wong, C. -H.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 130(36), 11945-11952
2006Sugar-Assisted ligation (SAL) of N-linked Glycopeptides with Broad Sequence Tolerance at the Ligation JunctionBrik, A.; Ficht, S.; Yang, Y. -Y.; Bennett, C.; Wong, C. -H.J. Am. Chem. Soc 128(46), 15026-33
2007Sugar-assisted ligation in glycoprotein synthesisYang, Y. Y.; Ficht, S.; Brik, A.; Wong, C. H.J Am Chem Soc 129, 7690-7701
2005Tetrabutylammonium fluoride-assisted rapid N(9)-alkylation on purine ring: Application to combinatorial reactions in microtiter plates for the discovery of potent sulfotransferase inhibitors in situ.Brik, A.; Wu, C. Y.; Best, M. D.; Wong, C. H.Bioorganic & medicinal chemistry 13(15), 4622-4626
2005Tetrabutylammonium Fluoride-Mediated Rapid Alkylation Reaction in Microtiter Plates for Discovery of Enzyme Inhibitors in SituWu, C. Y.; Brik, A.; Wang, S. K.; Chen, Y. H.; Wong, C. H.Chembiochem 6, 2176-2180
2005Tetrabutylammonium fluoride-mediated rapid alkylation reaction in microtiter plates for the discovery of enzyme inhibitors in situWu, C. Y.; Brik, A.; Wang, S. K.; Chen, Y. H.; Wong, C. H.Chembiochem 6, 2176-2180
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