研究成果

第 1 到 22 筆結果，共 22 筆。

公開日期題名作者關聯scopusWOS全文
12024Sulfated disaccharide protects membrane and DNA damages from arginine-rich dipeptide repeats in ALSYu-Jen Chang; Kai-Tai Lin; Orion Shih; Chi-Hua Yang; Ching-Yu Chuang; Ming-Han Fang; Wei-Bin Lai; Yi-Chung Lee; Hung-Chih Kuo ; Shang-Cheng Hung ; Chi-Kuang Yao ; U-Ser Jeng; Yun-Ru Chen SCIENCE ADVANCES 10(8), eadj0347
22023Galectin-3 aggravates microglial activation and tau transmission in tauopathySiew, Jian Jing; Chen, Hui-Mei; Chiu, Feng-Lan; Lee, Chia-Wei; Chang, Yao-Ming ; Chen, Hung-Lin ; Nguyen, Thi Ngoc Anh; Liao, Hung-Ting; Liu, Mengyu; Hagar, Hsiao-Tien; Sun, Yung-Chen; Lai, Hsing-Lin; Kuo, Min-Hao; Blum, David; Buée, Luc; Jin, Lee-Way; Chen, Shih-Yu ; Ko, Tai-Ming ; Huang, Jie-Rong; Kuo, Hung-Chih ; Liu, Fu-Tong ; Chern, Yijuang Journal of Clinical Investigation 134(2), e165523
32023Biocompatible neuronal stimulant-embedded poly(γ-benzyl-L-glutamate) peptide-based scaffolds promote differentiation, growth and functional maturation of human induced pluripotent stem cell-derived retinal ganglion cellsChen, TC; Chou, YJ; Wu, YX; Lo, JE; Lin, CY; Tseng, YH; Chu, YC; Chen, WL; Hu, FR; Su, WF; Kuo, HC Journal of the Taiwan Institute of Chemical Engineers 163, 105257
42023Amyloid Modifier SERF1a Interacts with PolyQ-expanded Huntingtin-Exon 1 via Helical Interactions and Exacerbates PolyQ-induced ToxicityTien-Ying Tsai§; Chun-Yu Chen§; Tien-Wei Lin; Tien-Chang Lin; Feng-Lan Chiu; Orion Shih; Ming-Yun Chang; Yu-Chun Lin; An-Chung Su; U-Ser Jeng; Hung-Chih Kuo ; Chi-Fon Chang ; Yun-Ru Chen Communications Biology 6, 767
52022TRAX Provides Neuroprotection for Huntington's Disease Via Modulating a Novel Subset of MicroRNAsYu-Ting Weng; Hui-Mei Chen; Ting Chien; Feng-Lan Chiu; Hung-Chih Kuo ; Yijuang Chern Movement Disorders 37(10), 2008-2020
62022Chemical interference with DSIF complex formation lowers synthesis of mutant huntingtin gene products and curtails mutant phenotypesDeng, N; Wu, YY; Feng, Y; Hsieh, WC; Song, JS; Lin, YS; Tseng, YH; Liao, WJ; Chu, YF; Liu, YC; Chang, EC; Liu, CR; Sheu, SY; Su, MT; Kuo, HC ; Cohen, SN; Cheng, THPNAS 119(32), e2204779119
72022Central nervous system organoids for modeling neurodegenerative diseasesHou, PS; Kuo, HC IUBMB LIFE 74(8), 812-825
82022Modeling Human Primary Microcephaly With hiPSC-Derived Brain Organoids Carrying CPAP-E1235V Disease-Associated Mutant ProteinAn, HL; Kuo, HC ; Tang, TK FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 10, 830432
92021Usp11 controls cortical neurogenesis and neuronal migration through Sox11 stabilizationChiang, Shang-Yin; Wu, Hsin-Chieh; Lin, Shu-Yu ; Chen, Hsin-Yi; Wang, Chia-Fang; Yeh, Nai-Hsing; Shih, Jou-Ho; Huang, Yi-Shuian ; Kuo, Hung-Chih ; Chou, Shen-Ju ; Chen, Ruey-Hwa Science advances 7(7), eabc6093
102021A system-wide mislocalization of RNA-binding proteins in motor neurons is a new feature of ALSLiu, Yu-Ju; Kuo, Hung-Chih ; Chern, Yijuang Neurobiology of Disease 160, 105531
112020Functional roles and networks of noncoding RNAs in the pathogenesis of neurodegenerative diseasesWu, YY; Kuo, HC JOURNAL OF BIOMEDICAL SCIENCE 27, 49
122019Using Human Pompe Disease Induced Pluripotent Stem Cells-derived Neural Cells for Identifying Chemicals with Therapeutic PotentialHuang, HP; Chiang, W; Chuang, CY; Stone, L; Kang, CK; Hwu, WL; Kuo, HC HUMAN MOLECULAR GENETICS 28(23), 3880-3894
132019Aryl hydrocarbon receptor modulates stroke-induced astrogliosis and neurogenesis in the adult mouse brainChen, WC; Chang, LH; Huang, SS; Huang, YJ; Chih, CL; Kuo, HC ; Lee, YH; Lee, IHJOURNAL OF NEUROINFLAMMATION 16, 187
142019Hyperactive CREB signaling pathway involved in the pathogenesis of polycystic ovarian syndrome revealed by patient-specific induced pluripotent stem cell modeling.Huang, CC; Chen, MJ; Lan, CW; Wu, CE; Huang, MC; Kuo, HC ; Ho, HNFERTILITY AND STERILITY 112(3), 594-607.e12
152019The emerging roles and functions of circular RNAs and their generationYu, CY; Kuo, HC JOURNAL OF BIOMEDICAL SCIENCE 26, 29
162019Modeling spinocerebellar ataxias 2 and 3 with iPSCs reveals a role for glutamate in disease pathologyChuang, CY; Yang, CC; Soong, BW; Yu, CY; Chen, SH; Huang, HP; Kuo, HC SCIENTIFIC REPORTS 9, 1166
172019Opportunities and challenges for the use of induced pluripotent stem cells in modelling neurodegenerative diseaseWu, YY; Chiu, FL; Yeh, CS; Kuo, HC OPEN BIOLOGY 9(1), 180177
182018Integrative transcriptome sequencing reveals extensive alternative trans-splicing and cis-backsplicing in human cellsChuang, Trees-Juen ; Chen, Yen-Ju; Chen, Chia-Ying; Mai, Te-Lun; Wang, Yi-Da; Yeh, Chung­Shu; Yang, Min-Yu; Hsiao, Yu-Ting; Chang, Tien-Hsien ; Kuo, Tzu-Chien; Cho, Hsin-Hua; Shen, Chia-Ning  ; Kuo, Hung-Chih ; Lu, Mei-Yeh ; Chen, Yi-Hua; Hsieh, Shan-Chi; Chiang, Tai-WeiNUCLEIC ACIDS RESEARCH 46(7), 3671-3691
192017The circular RNA circBIRC6 participates in the molecular circuitry controlling human pluripotencyYu, CY; Li, TC; Wu, YY; Yeh, CH; Chiang, W; Chuang, CY; Kuo, HC NATURE COMMUNICATIONS 8, 1149
202017Direct conversion of human fibroblasts into neural progenitors via the use of transcription factors highly enriched in human ESC-derived neural progenitorsHou, PS; Chuang, CY; Yeh, CH; Chiang, W; Liu, HJ; Lin, TN; Kuo, HC STEM CELL REPORTS 8(1), 54-68
212014Suppression of the SOX2 neural effector gene by PRDM1 promotes human germ cell fate in embryonic stem cellsI-Ying Lin; Feng-Lan Chiu; Chen-Hsiang Yeang ; Hsin-Fu Chen; Ching-Yu Chuang; Shii-Yi Yang; Pei-Shan Hou; Nardnisa Sintupisut; Hong-Nerng Ho; Hung-Chih Kuo ; Kuo-I Lin Stem Cell Reports 2(2), 189-204
222011Surface marker epithelial cell adhesion molecule and E-cadherin facilitate the identification and selection of induced pluripotent stem cellsChen, HF; Chuang, CY; Lee, WC; Huang, HP; Wu, HC ; Ho, HN; Chen, YJ ; Kuo, HC STEM CELL REVIEWS 7(3), 722-735