Publications

Results 1-30 of 30 (Search time: 0.005 seconds).

Issue DateTitleAuthor(s)RelationscopusWOSFulltext/Archive link
12023Signal peptide-CUB-EGF-like repeat-containing protein 1-promoted FLT3 signaling is critical for the initiation and maintenance of MLL-rearranged acute leukemiaBinay K. Sahoo; Yuh-Charn Lin; Cheng-Fen Tu; Chien-Chin Lin; Wei-Ju Liao; Fu-An Li ; Ling-Hui Li ; Kurt Yun Mou; Steve R. Roffler ; Shu-Ping Wang ; Chi-Tai Yeh; Chi-Yuan Yao; Hsin-An Hou; Wen-Chien Chou; Hwei-Fang Tien; Ruey-Bing Yang Haematologica 108(5), 1284-1299
22023Accelerated clearance by antibodies against methoxy PEG depends on pegylation architectureLin, YC; Chen, BM; Tran, TTM; Chang, TC; Al-Qaisi, TS; Roffler, SR Journal of Controlled Release 354, 354-367
32023Anti-PEG antibodies before and after a first dose of Comirnaty® (mRNA-LNP-based SARS-CoV-2 vaccine)Bavli, Y; Chen, BM; Gross, G; Hershko, A; Turjeman, K; Roffler, S ; Barenholz, YJournal of Controlled Release 354, 316-322
42022Glucuronides: From biological waste to bio-nanomedical applicationsBurnouf, PA; Roffler, SR ; Wu, CC; Su, YCJournal of controlled release : official journal of the Controlled Release Society 349, 765-782
52022Structural determination of an antibody that specifically recognizes polyethylene glycol with a terminal methoxy groupNguyen, MT; Shih, YC; Lin, MH; Roffler, SR ; Hsiao, CY; Cheng, TL; Lin, WW; Lin, EC; Jong, YJ; Chang, CY; Su, YCCommunications chemistry 5(1), 88
62022Development of Irinotecan Liposome Armed with Dual-Target Anti-Epidermal Growth Factor Receptor and Anti-Fibroblast Activation Protein-Specific Antibody for Pancreatic Cancer TreatmentLin, HJ; Liang, TL; Chang, YY; Liu, DZ; Fan, JY; Roffler, SR ; Lin, SYPharmaceutics 14(6), 1202
72022Translational development of a tumor junction opening technologyKim, J; Li, C; Wang, H; Kaviraj, S; Singh, S; Savergave, L; Raghuwanshi, A; Gil, S; Germond, A; Baldessari, A; Chen, B; Roffler, S ; Fender, P; Drescher, C; Carter, D; Lieber, AScientific reports 12(1), 7753
82022Bispecific T-cell engagers non-covalently decorated drug-loaded PEGylated nanocarriers for cancer immunochemotherapyCheng, WJ; Chuang, KH; Lo, YJ; Chen, M; Chen, YJ; Roffler, SR ; Ho, HO; Lin, SY; Sheu, MTJournal of Controlled Release 344, 235-248
92022In Vivo Hematopoietic Stem Cell Gene Therapy for SARS-CoV2 Infection Using a Decoy ReceptorWang, H; Li, C; Obadan, AO; Frizzell, H; Hsiang, TY; Gil, S; Germond, A; Fountain, C; Baldessari, A; Roffler, S ; Kiem, HP; Fuller, DH; Lieber, AHuman gene therapy 33(7-8), 389-403
102022Inhibition of gut microbial β-glucuronidase effectively prevents carcinogen-induced microbial dysbiosis and intestinal tumorigenesisCheng, KW; Tseng, CH; Chen, IJ; Huang, BC; Liu, HJ; Ho, KW; Lin, WW; Chuang, CH; Huang, MY; Leu, YL; Roffler, SR ; Wang, JY; Chen, YL; Cheng, TLPharmacological research 177, 106115
112022The interplay between membrane topology and mechanical forces in regulating T cell receptor activityAl-Aghbar, MA; Jainarayanan, AK; Dustin, ML; Roffler, SR Communications biology 5(1), 40
122021Impact of anti-PEG antibody affinity on accelerated blood clearance of pegylated epoetin beta in miceChang, TC; Chen, BM; Wu, JY; Cheng, TL; Roffler, S Biomedicine & pharmacotherapy 146, 112502
132021A novel anti-tumor/anti-tumor-associated fibroblast/anti-mPEG tri-specific antibody to maximize the efficacy of mPEGylated nanomedicines against fibroblast-rich solid tumorChen, M; Sheu, MT; Cheng, TL; Roffler, SR ; Lin, SY; Chen, YJ; Cheng, YA; Cheng, JJ; Chang, HY; Wu, TY; Kao, AP; Ho, YS; Chuang, KHBiomaterials science 10(1), 202-215
142021Polyethylene Glycol Immunogenicity: Theoretical, Clinical, and Practical Aspects of Anti-Polyethylene Glycol AntibodiesChen, BM; Cheng, TL; Roffler, SR ACS nano 15(9), 14022-14048
152021Entropy-driven binding of gut bacterial β-glucuronidase inhibitors ameliorates irinotecan-induced toxicityLin, HY; Chen, CY; Lin, TC; Yeh, LF; Hsieh, WC; Gao, S; Burnouf, PA; Chen, BM; Hsieh, TJ; Dashnyam, P; Kuo, YH; Tu, Z; Roffler, SR ; Lin, CHCommunications biology 4, 280
162021Replacement of L-amino acid peptides with D-amino acid peptides mitigates anti-PEG antibody generation against polymer-peptide conjugates in miceSylvestre, M; Lv, S; Yang, LF; Luera, N; Peeler, DJ; Chen, BM; Roffler, SR ; Pun, SHJournal of controlled release : official journal of the Controlled Release Society 331, 142-153
172021Double attack strategy for leukemia using a pre-targeting bispecific antibody (CD20 Ab-mPEG scFv) and actively attracting PEGylated liposomal doxorubicin to enhance anti-tumor activityHo, KW; Chen, IU; Cheng, YA; Liao, TY; Liu, ES; Chen, HJ; Lu, YC; Su, YC; Roffler, SR ; Huang, BC; Liu, HJ; Huang, MY; Chen, CY; Cheng, TLJournal of nanobiotechnology 19, 16
182021Flow cytometry analysis of anti-polyethylene glycol antibodies in human plasmaFang, JL; Beland, FA; Tang, Y; Roffler, SR Toxicology reports 8, 148-154
192020Bispecific antibody (HER2 × mPEG) enhances anti-cancer effects by precise targeting and accumulation of mPEGylated liposomesChen, I-Ju; Cheng, Yi-An; Ho, Kai-Wen; Lin, Wen-Wei; Cheng, Kai-Wen; Lu, Yun-Chi; Hsieh, Yuan-Chin; Huang, Chien-Chiao; Chuang, Chih-Hung; Chen, Fang-Ming; Su, Yu-Cheng; Roffler, Steve R. ; Cheng, Tian-LuActa Biomaterialia 111, 386-397
202020Premature Drug Release from Polyethylene Glycol (PEG)-Coated Liposomal Doxorubicin via Formation of the Membrane Attack ComplexChen, E; Chen, BM; Su, YC; Chang, YC ; Cheng, TL; Barenholz, Y; Roffler, SR ACS nano 14(7), 7808-7822
212020Structural basis of polyethylene glycol recognition by antibody.Lee, CC; Su, YC; Ko, TP; Lin, LL; Yang, CY; Chang, SS; Roffler, SR ; Wang, AHJournal of biomedical science 27, 12
222020PEGylated Liposomal Methyl Prednisolone Succinate does not Induce Infusion Reactions in Patients: A Correlation Between in Vitro Immunological and in Vivo Clinical Studies.Bavli, Y; Chen, BM; Roffler, SR ; Dobrovolskaia, MA; Elnekave, E; Ash, S; Barenholz, Y; Turjeman, KMolecules (Basel, Switzerland) 25(3), 558
232019Both IgM and IgG Antibodies Against Polyethylene Glycol Can Alter the Biological Activity of Methoxy Polyethylene Glycol-Epoetin Beta in Mice.Chang, TC; Chen, BM; Lin, WW; Yu, PH; Chiu, YW; Chen, YT; Wu, JY; Cheng, TL; Hwang, DY; Roffler, SR Pharmaceutics 12(1), 15
242019Enhanced drug internalization and therapeutic efficacy of PEGylated nanoparticles by one-step formulation with anti-mPEG bispecific antibody in intrinsic drug-resistant breast cancer.Cheng, YA; Chen, IJ; Su, YC; Cheng, KW; Lu, YC; Lin, WW; Hsieh, YC; Kao, CH; Chen, FM; Roffler, SR ; Cheng, TLBiomaterials science 7(8), 3404-3417
252019Simply Mixing Poly Protein G with Detection Antibodies Enhances the Detection Limit and Sensitivity of Immunoassays.Chen, YJ; Chen, M; Cheng, TL; Roffler, SR ; Lin, SY; Hsu, HL; Wang, CH; Chen, CY; Kao, AP; Cheng, JJ; Chuang, KHAnalytical chemistry 91(13), 8310-8317
262019Doxebo (doxorubicin-free Doxil-like liposomes) is safe to use as a pre-treatment to prevent infusion reactions to PEGylated nanodrugs.Bavli, Y; Winkler, I; Chen, BM; Roffler, S ; Cohen, R; Szebeni, J; Barenholz, YJournal of controlled release : official journal of the Controlled Release Society 306, 138-148
272017The Affinity of Elongated Membrane-Tethered Ligands Determines Potency of T Cell Receptor TriggeringChen, Bing-Mae; Al-Aghbar, Mohammad Ameen; Lee, Chien-Hsin; Chang, Tien-Ching; Su, Yu-Cheng; Li, Ya-Chen; Chang, Shih-En; Chen, Chin-Chuan; Chung, Tsai-Hua; Liao, Yuan-Chun; Lee, Chau-Hwang ; Roffler, Steve R FRONTIERS IN IMMUNOLOGY 8, 793
282017Conditional internalization of PEGylated nanomedicines by PEG engagers for triple negative breast cancer therapy.Su, YC; Burnouf, PA; Chuang, KH; Chen, BM; Cheng, TL; Roffler, SR NATURE COMMUNICATIONS 8, 15507
292017Enhancement Effect of a Variable Topology of a Membrane-Tethered Anti-Poly(ethylene glycol) Antibody on the Sensitivity for Quantifying PEG and PEGylated Molecules.Lin, WW; Cheng, YA; Kao, CH; Roffler, SR ; Lee, YC; Chen, BM; Hsieh, YC; Chen, IJ; Huang, BC; Wang, YT; Tung, YC; Huang, MY; Chen, FM; Cheng, TLANALYTICAL CHEMISTRY 89(11), 6082-6090
302008Directed evolution of a lysosomal enzyme with enhanced activity at neutral pH by mammalian cell-surface display.Chen, KC; Wu, CH; Chang, CY; Lu, WC; Tseng, Q; Prijovich, ZM; Schechinger, W; Liaw, YC ; Leu, YL; Roffler, SR Chemistry & Biology 15(12), 1277-1286