研究成果

第 1 到 31 筆結果，共 31 筆。

公開日期題名作者關聯scopusWOS全文
12023A strategy for evaluating potential antiviral resistance to small molecule drugs and application to SARS-CoV-2Karen Sargsyan; Karine Mazmanian; Carmay Lim SCIENTIFIC REPORTS 13, 502
22022A g-tubulin complex-dependent pathway suppresses unscheduled ciliogenensis by promoting cilia disassemblySahana Shankar; Zi-Ting Hsu; Artur Ezquerra; Chien-Chien Li; Tzu-Lun Huang; Etienne Coyaud; Cédric Grauffel; Brian Raught; Carmay Lim ; Jens Lüders; Su-Yi Tsai; Kuo-Chiang HsiaCell Reports 41(7), 111642
32022Factors Allowing Small Monovalent Li+ to Displace Ca2+ in ProteinsCédric Grauffel; Wei-Hsiang Weng; Carmay Lim Physical Chemistry Chemical Physics 24(29), 17759-17769
42022Allosteric coupling between transmembrane segment 4 and the selectivity filter of TALK1 potassium channels regulates their gating by extracellular pHWen-Hao Tsai; Cédric Grauffel; Ming-Yueh Huang ; Sandra Postić; Marjan Slak Rupnik; Carmay Lim ; Shi-Bing Yang JOURNAL OF BIOLOGICAL CHEMISTRY 298(6), 101998
52022Efficient strategy to design protease inhibitors: Application to enterovirus 71 2A proteaseTing Chen; Cédric Grauffel; Wei-Zen Yang; Yi-Ping Chen; Hanna S. Yuan ; Carmay Lim ACS Bio & Med Chem Au 2(4), 437-449
62022From quantum-derived principles underlying cysteine reactivity to combating the COVID-19 pandemicKarine Mazmanian; Ting Chen; Karen Sargsyan; Carmay Lim WIRES Computational Molecular Science 12(5), e1607
72022PPI-HotspotDB: Database of Protein–Protein Interaction Hot SpotsYao Chi Chen; Yu-Hsien Chen; Jon D. Wright; Carmay Lim Journal of Chemical Information and Modeling 62(4), 1052-1060
82021Calcium in signaling: Its specificity and vulnerabilities towards biogenic and abiogenic metal ionsTodor Dudev; Cedric Grauffel; Carmay Lim The Journal of Physical Chemistry B 125(37), 10419-10431
92021Trinuclear Calcium Site in the C2 Domain of PKCα/γ Is Prone to Lithium AttackCédric Grauffel; Wei-Hsiang Weng; Todor Dudev; Carmay Lim ACS Omega 6(31), 20657-20666
102021Influence of solution ionic strength on the stabilities of M20 loop conformations in apo E. coli dihydrofolate reductaseBabu, C. Satheesan; Lim, Carmay The Journal of Chemical Physics 154, 195103
112021Correction to “Synergistic Inhibition of SARS-CoV-2 Replication Using Disulfiram/Ebselen and Remdesivir”Chen, T; Fei, CY; Chen, YP; Sargsyan, K; Liang, JJ; Liao, CC ; Lin, YL ; Chang, CP; Yuan, HS ; Lim, C ACS pharmacology & translational science 4(3), 1246
122021Correction: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectorsSargsyan, Karen; Lin, Chien-Chu; Chen, Ting; Grauffel, Cédric; Chen, Yi-Ping; Yang, Wei-Zen; Liang, Jian-Jong; Liao, Chun-Che ; Lin, Yi-Ling ; Yuan, Hanna S. ; Lim, Carmay Chemical Science 12(17), 6210
132021Metal Affinity/Selectivity of Monophosphate-Containing Signaling/Lipid MoleculesGrauffel, Cédric; Dudev, Todor; Lim, Carmay Journal of Chemical Theory and Computation 17(4), 2444-2456
142021Synergistic Inhibition of SARS-CoV-2 Replication Using Disulfiram/Ebselen and RemdesivirChen, Ting; Fei, Cheng-Yin; Chen, Yi-Ping; Sargsyan, Karen; Chang, Chun-Ping; Yuan, Hanna S.; Lim, Carmay ACS Pharmacology & Translational Science 4(2), 898-907
152021Sensitive and Specific Cadmium Biosensor Developed by Reconfiguring Metal Transport and Leveraging Natural Gene RepositoriesHe, Mei-Ying; Lin, Yu-Jen; Kao, Yi-Ling; Kuo, Pu; Grauffel, Cédric; Lim, Carmay ; Cheng, Yi-Sheng; Chou, Hsin-Hung DavidACS Sensors 6(3), 995-1002
162020Benchmarking polarizable and non-polarizable force fields for Ca2+–peptides against a comprehensive QM datasetAmin, Kazi S.; Hu, Xiaojuan; Salahub, Dennis R.; Baldauf, Carsten; Lim, Carmay ; Noskov, SergeiThe Journal of Chemical Physics 153(14), 144102
172020Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectorsSargsyan, Karen; Lin, Chien-Chu; Chen, Ting; Grauffel, Cédric; Chen, Yi-Ping; Yang, Wei-Zen; Yuan, Hanna S.; Lim, Carmay Chemical Science 11(36), 9904-9909
182020Activation Free Energy, Substrate Binding Free Energy, and Enzyme Efficiency Fall in a Very Narrow Range of Values for Most EnzymesSousa, Sérgio F.; Calixto, Ana R.; Ferreira, Pedro; Ramos, Maria J.; Lim, Carmay ; Fernandes, Pedro A.ACS Catalysis 10(15), 8444-8453
192020How the local environment of functional sites regulates protein functionKarine Mazmanian; Karen Sargsyan; Carmay Lim JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 42(22), 9861-9871
202020Sensitivity of Functional Loop Conformations on Long-Range Electrostatics: Implications for M20 Loop Dynamics in E. coli Dihydrofolate ReductaseBabu, C. Satheesan; Lim, Carmay Journal of Chemical Theory and Computation 16(4), 2028-2033
212020Gene Silencing Mechanisms Revealed by Dynamics of Guide, Target and Duplex Binding to ArgonauteTai, Hui-Chung; Lim, Carmay Journal of Chemical Theory and Computation 16(1), 688-699
222019Why Cellular Di/Triphosphates Preferably Bind Mg2+ and Not Ca2+Grauffel, Cédric; Dudev, Todor; Lim, Carmay Journal of Chemical Theory and Computation 15(12), 6992-7003
232019Free and Bound Therapeutic Lithium in Brain SignalingDudev, Todor; Mazmanian, Karine; Weng, Wei-Hsiang; Grauffel, Cédric; Lim, Carmay Accounts of Chemical Research 52(10), 2960-2970
242019Factors Governing the Different Functions of Zn2+-Sites with Identical Ligands in Proteins.Lee, YM; Grauffel, C; Chen, T; Sargsyan, K; Lim, C Journal of chemical information and modeling 59(9), 3946-3954
252019Ran pathway-independent regulation of mitotic Golgi disassembly by Importin-αChang, CC; Chen, CJ; Grauffel, C; Pien, YC; Lim, C ; Tsai, SY; Hsia, KCNature communications 10(1), 4307
262019Soluble klotho regulates TRPC6 calcium signaling via lipid rafts, independent of the FGFR-FGF23 pathwayWright, Jon D.; An, Sung-Wan; Xie, Jian; Lim, Carmay ; Huang, Chou-LongThe FASEB Journal 33(8), 9182-9193
272018How Native and Non-Native Cations Bind and Modulate the Properties of GTP/ATPDudev, Todor; Grauffel, Cédric; Hsu, Shang-Te Danny ; Lim, Carmay Journal of Chemical Theory and Computation 14(6), 3311-3320
282017Modeled structural basis for the recognition of α2-3-sialyllactose by soluble KlothoWright, Jon D.; An, Sung-Wan; Xie, Jian; Yoon, Joonho; Nischan, Nicole; Kohler, Jennifer J.; Oliver, Noelynn; Lim, Carmay ; Huang, Chou-LongThe FASEB Journal 31(8), 3574-3586
292017NADPH_C. Satheesan Babu; Carmay Lim 
302016Structural Basis for the Magnesium-Dependent Activation and Hexamerization of the Lon AAA+ ProteaseSu, SC; Lin, CC; Tai, HC; Chang, MY; Ho, MR ; Babu, CS; Liao, JH; Wu, SH ; Chang, YC ; Lim, C ; Chang, CI Structure 24(5), 676-686
311996Positive charge at position 549 is essential for phosphatidylinositol 4,5-bisphosphate-hydrolyzing but not phosphatidylinositol-hydrolyzing activities of human phospholipase C delta1Wang, LP; Lim, C ; Kuan, Y ; Chen, CL; Chen, HF; King, KJournal of Biological Chemistry 271(40), 24505-24516