Publications

Results 1-106 of 106 (Search time: 0.004 seconds).

Issue DateTitleAuthor(s)RelationscopusWOSFulltext/Archive link
12021Simeprevir Potently Suppresses SARS-CoV-2 Replication and Synergizes with RemdesivirLo, HS; Hui, KPY; Lai, HM; He, X; Khan, KS; Kaur, S; Huang, J; Li, Z; Chan, AKN; Cheung, HH; Ng, KC; Ho, JCW; Chen, YW; Ma, B; Cheung, PM; Shin, D; Wang, K; Lee, MH; Selisko, B; Eydoux, C; Guillemot, JC; Canard, B; Wu, KP ; Liang, PH ; Dikic, I; Zuo, Z; Chan, FKL; Hui, DSC; Mok, VCT; Wong, KB; Mok, CKP; Ko, H; Aik, WS; Chan, MCW; Ng, WLACS central science 7(5), 792-802
22016Fluorescent Farnesyl Diphosphate Analogue: A Probe To Validate trans-Prenyltransferase Inhibitors.Kuo-Hsun Teng; Erh-Ting Hsu; Ying-Hsuan Chang; Sheng-Wei Lin ; Po-Huang Liang BIOCHEMISTRY 55(31), 4366-4374
32016Identification, synthesis and evaluation of SARS-CoV and MERS-CoV 3C-like protease inhibitors.Kumar, V; Tan, KP; Wang, YM; Lin, SW ; Liang, PH Bioorganic & medicinal chemistry 24(13), 3035-3042
42015Crystal structures of ligand-bound octaprenyl pyrophosphate synthase from Escherichia coli reveal the catalytic and chain-length determining mechanisms.Han, X; Chen, CC; Kuo, CJ; Huang, CH; Zheng, Y; Ko, TP; Zhu, Z; Feng, X; Wang, K; Oldfield, E; Wang, AH ; Liang, PH ; Guo, RT; Ma, YProteins 83(1), 37-45
52015Biochemical Characterization and Structural Analysis of a Bifunctional Cellulase/Xylanase from Clostridium thermocellum.Yuan, SF; Wu, TH; Lee, HL; Hsieh, HY; Lin, WL; Yang, B; Chang, CK; Li, Q; Gao, J; Huang, CH; Ho, MC ; Guo, RT; Liang, PH The Journal of biological chemistry 290(9), 5739-5748
6201302.知識饗宴「蛋白質生技及藥物研發」梁博煌 
72012Targeting β-tubulin:CCT-β complexes incurs Hsp90- and VCP-related protein degradation and induces ER stress-associated apoptosis by triggering capacitative Ca2+ entry, mitochondrial perturbation and caspase overactivationLin, YF; Lee, YF; Liang, PH Cell Death & Disease 3, e434
82012Mutations in the substrate entrance region of β-glucosidase from Trichoderma reesei improve enzyme activity and thermostabilityLee, HL; Chang, CK; Jeng, WY; Wang, AH ; Liang, PH Protein engineering design & selection 25(11), 733-740
92012Structures, mechanisms and inhibitors of undecaprenyl diphosphate synthase: A cis-prenyltransferase for bacterial peptidoglycan biosynthesisTeng, KH; Liang, PH BIOORGANIC CHEMISTRY 43, 51-57
102012Roles of Amino Acids in the Escherichia coli Octaprenyl Diphosphate Synthase Active Site Probed by Structure-Guided Site-Directed Mutagenesis.Chang, KM; Chen, SH; Kuo, CJ; Chang, CK; Guo, RT; Yang, JM; Liang, PH BIOCHEMISTRY 51(6), 3412-3419
112012Insights into the Mechanism of the Antibiotic-Synthesizing Enzyme MoeO5 from Crystal Structures of Different Complexes.Ren, F; Ko, TP; Feng, X; Huang, CH; Chan, HC; Hu, Y; Wang, K; Ma, Y; Liang, PH ; Wang, AH; Oldfield, E; Guo, RTANGEWANDTE CHEMIE-INTERNATIONAL EDITION 51(17), 4157-4160
122012Structure of the catalytic domain of the Clostridium thermocellum cellulase CelTKesavulu, MM; Tsai, JY; Lee, HL; Liang, PH ; Hsiao, CD Acta Crystallographica Section D: Biological Crystallography D68, 310-320
132012Undecaprenyl diphosphate synthase, a cis-prenyltransferase synthesizing lipid carrier for bacterial cell wall biosynthesis.Teng, KH; Liang, PH Molecular membrane biology 29(7), 267-273
142011Recent development of 3C and 3CL protease inhibitors for anti-coronavirus and anti-picornavirus drug discoveryRamajayam, R; Tan, KP; Liang, PH BIOCHEMICAL SOCIETY TRANSACTIONS 39(5), 1371-1375
152011Fluorescent substrate analog for monitoring chain elongation by undecaprenyl pyrophosphate synthase in real time.Teng, KH; Chen, AP; Kuo, CJ; Li, YC; Liu, HG; Chen, CT; Liang, PH Analytical biochemistry 417(1), 136-141
162011Construction and characterization of different fusion proteins between cellulases and β-glucosidase to improve glucose production and thermostability.Lee, HL; Chang, CK; Teng, KH; Liang, PH BIORESOURCE TECHNOLOGY 102(4), 3973-3976
172011Repression of btuB gene transcription in Escherichia coli by the GadX proteinLei, GS; Syu, WJ; Liang, PH ; Chak, KF; Hu, WS; Hu, STBMC MICROBIOLOGY 11(1), 33
182011Structural and functional analysis of three β-glucosidases from bacterium Clostridium cellulovorans, fungus Trichoderma reesei and termite Neotermes koshunensisJeng, WY; Wang, NC; Lin, MH; Lin, CT; Liaw, YC ; Chang, WJ; Liu, CI; Liang, PH ; Wang, AHJ Journal of structural biology 173(1), 46-56
192011Kinetic, mechanistic, structural and inhibitory aspects of the cis-prenyltransferase catalyzed lipid chain elongation.Liang, PH CHEMISTRY AND PHYSICS OF LIPIDS 164(S1), S12-S14
202010Synthesis and evaluation of pyrazolone compounds as SARS-coronavirus 3C-like protease nhibitorsRamajayam, R; Tan, KP; Liu, HG; Liang, PH BIOORGANIC & MEDICINAL CHEMISTRY 18(22), 7849-7854
212010Mechanism of cis-prenyltransferase reaction probed by substrate analoguesLu, YP; Liu, HG; Teng, KH; Liang, PH BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 400(4), 758-762
222010Synthesis, docking studies, and evaluation of pyrimidines as inhibitors of SARS-CoV 3CL proteaseRamajayam, R; Tan, KP; Liu, HG; Liang, PH Bioorganic & medicinal chemistry letters 20(12), 3569-3572
232010Structure of a Heterotetrameric Geranyl Pyrophosphate Synthase from Mint (Mentha piperita) Reveals Intersubunit Regulation.Chang, TH; Hsieh, FL; Ko, TP; Teng, KH; Liang, PH ; Wang, AHJ The Plant Cell 22(2), 454-467
242010Learning to predict expression efficacy of vectors in recombinant protein productionChan, WC; Liang, PH ; Shih, YP; Yang, UC; Lin, WC; Hsu, CNBMC Bioinformatics 11(Suppl 1), S21
252010Picornaviral 3C protease inhibitors and the dual 3C protease/coronaviral 3C-like protease inhibitors.Wang, HM; Liang, PH Expert opinion on therapeutic patents 20(1), 59-71
262010Synthesis and evaluation of benzoquinolinone derivatives as SARS-CoV 3CL protease inhibitorsAhn, TY; Kuo, CJ; Liu, HG; Ha, DC; Liang, PH ; Jung, YSBULLETIN OF THE KOREAN CHEMICAL SOCIETY 31(01), 87-91
272009Engineering a novel endopeptidase based on SARS 3CLproKuo, CJ; Shih, YP; Kan, D; Liang, PH BioTechniques 47(6), 1029–1032
282009Parallel gene cloning and protein production in multiple expression systemsWang, HM; Shih, YP; Hu, SM; Lo, WT; Lin, HM; Ding, SS; Liao, HC; Liang, PH Biotechnology Progress 25(6), 1582-6
292009Combined experimental and theoretical study of long-range interactions modulating dimerization and activity of yeast geranylgeranyl diphosphate synthaseLo, CH; Chang, YH; Wright, JD; Chen, SH; Kan, D; Lim, C; Liang, PH Journal of the American Chemical Society 131, 4051-4062
302009Different reaction mechanisms for cis- and trans-prenyltransferases.Lu, YP; Liu, HG; Liang, PH Biochemical and biophysical research communications 379(2), 351-355
312009Reaction kinetics, catalytic mechanisms, conformational changes, and inhibitor design for prenyltransferasesLiang, PH Biochemistry 48, 6562-6570
322009Individual and common inhibitors of coronavirus and picornavirus main proteases.Kuo, CJ; Liu, HG; Lo, YK; Seong, CM; Lee, KI; Jung, YS; Liang, PH FEBS letters 583(3), 549-555
332009Intracellular beta-tubulin/Chaperonin containing TCP1-beta complex serves as a novel chemotherapeutic target against drug-resistant tumorsLin, YF; Tsai, WP; Liu, HG; Liang, PH Cancer Research 69, 6879-6888
342009Structural basis of inhibition specificities of 3C and 3C-like proteases by zinc-coordinating and peptidomimetic compounds.Lee, CC; Kuo, CJ; Ko, TP; Hsu, MF; Tsui, YC; Chang, SC; Yang, S; Chen, SJ; Chen, HC; Hsu, MC; Shih, SR; Liang, PH ; Wang, AHThe Journal of biological chemistry 284(12), 7646-7655
352008Design, Synthesis, and Evaluation of Trifluoromethyl Ketones as Inhibitors of SARS-CoV 3CL ProteaseShao, Y. -M.; Yang, W. -B. ; Kuo, T. -H.; Tsai, K. -C.; Lin, C. -H. ; Yang, A. -S. ; Liang, P. -H. ; Wong, C. -H. Bioorganic & Medicinal Chemistry 16(8), 4652-4660
362008A mammalian cell-based reverse two-hybrid system for functional analysis of 3C viral protease of human enterovirus 71Lee, JC; Shih, SR; Chang, TY; Tseng, HY; Shih, YF; Yen, KJ; Chen, WC; Shie, JJ; Fang, JM; Liang, PH ; Chao, YS; Hsu, JTAnal Biochemistry 375, 115-123
372008Structure-based inhibitors exhibit differential activities against Helicobacter pylori and Escherichia coli undecaprenyl pyrophosphate synthasesKuo, CJ; Guo, RT; Lu, IL; Liu, HG; Wu, SY; Ko, TP; Wang, AHJ ; Liang, PH Journal of biomedicine & biotechnolog 2008, 841312
382008Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation.Chen, C K-M; Hudock, MP; Zhang, Y; Guo, RT; Cao, R; No, JH; Liang, PH ; Ko, TP; Chang, TH; Chang, SC; Song, Y; Axelson, J; Kumar, A; Wang, AHJ ; Oldfield, EJournal of medicinal chemistry 51(18), 5594-5607
392008Design, synthesis, and evaluation of 3C protease inhibitors as anti-enterovirus 71 agentsKuo, CJ; Shie, JJ; Fang, JM; Yen, GR; Hsu, JT; Liu, HG; Tseng, SN; Chang, SC; Lee, CY; Shih, SR; Liang, PH BIOORGANIC & MEDICINAL CHEMISTRY 16, 7388-7398
402007Structure-Based Design and Synthesis of Highly Potent SARS-CoV 3CL Protease InhibitorsShao, Y. M.; Yang, W. B. ; Peng, H. P.; Hsu, M. F.; Tsai, K. C.; Kuo, T. H.; Wang, A. H. J. ; Liang, P. H. ; Lin, C. H. ; Yang, A. S. ; Wong, C. H. ChemBioChem 8(14), 1654-1657
412007Structural basis of mercury- and zinc-conjugated complexes as SARS-CoV 3C-like protease inhibitors.Lee, CC; Kuo, CJ; Hsu, MF; Liang, PH ; Fang, JM; Shie, JJ; Wang, AHJ FEBS letters 581(28), 5454-5458
422007Bisphosphonates target multiple sites in both cis- and trans-prenyltransferasesGuo, RT; Cao, R; Liang, PH ; Ko, TP; Chang, TH; Hudock, MP; Jeng, WY; Chen, CK; Zhang, Y; Song, Y; Kuo, CJ; Yin, F; Oldfield, E; Wang, AHJ PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 104(24), 10022-10027
432007Drug discovery for SARS and other human coronaviruses targeting 3C proteasesLiang, PH Drugs of the Future 32, 29-29
442007Specific Plant Terpenoids and Lignoids Possess Potent Antiviral Activities against Severe Acute Respiratory Syndrome CoronavirusWen, CC; Kuo, YH; Jan, JT; Liang, PH ; Wang, SY; Liu, HG; Lee, CK; Chang, ST; Kuo, CJ; Lee, SS; Hou, CC; Hsiao, PW; Chien, SC; Shyur, LF; Yang, NSJ Med Chem 50, 4087-4095
452007Novel small-molecule inhibitors of transmissible gastroenteritis virusYang, CW; Yang, YN; Liang, PH ; Chen, CM; Chen, WL; Chang, HY; Chao, YS; Lee, SJAntimicrob Agents Chemother 51(11), 3924-3931
462007Pharmacophores and biological activities of severe respiratory syndrome viral protease inhibitorsWang, HM; Liang, PH Expert Opinion on Therapeutic Patents 17, 533-546
472006Crystal structure of type-III geranylgeranyl pyrophosphate synthase from Saccharomyces cerevisiae and the mechanism of product chain length determinationChang, TH; Guo, RT; Ko, TP; Wang, AHJ ; Liang, PH The Journal of biological chemistry 281(21), 14991-15000
482006An E. coli lon mutant conferring partial resistance to colicin may reveal a novel role in regulating proteins involved in the translocation of colicinLee, YY; Hu, HT; Liang, PH ; Chak, KFBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 345, 1579-1585
492006Discovery of a novel family of SARS-CoV protease inhibitors by virtual screening and 3D-QSAR studiesTsai, KC; Chen, SY; Liang, PH ; Lu, IL; Mahindroo, N; Hsieh, HP; Chao, YS; Liu, L; Liu, D; Lien, W; Lin, TH; Wu, SYJ Med Chem 49, 3485-3495
502006Ligand specificities and structural requirements of two Tachypleus plasma lectins for bacterial trappingKuo, TH; Chuang, SC; Chang, SY; Liang, PH Biochem J 393, 757-766
512006Characterization and inhibition of SARS-coronavirus main proteaseLiang, PH Current Topics in Medicinal Chemistry 6, 361-376
522006Stable benzotriazole esters as mechanism-based inhibitors of the severe acute respiratory syndrome 3CL proteaseWu, CY; King, KY; Kuo, CJ; Fang, JM; Wu, YT; Ho, MY; Liao, CL; Shie, JJ; Liang, PH ; Wong, CHChem Biol 13, 261-268
532006Structure-Based Drug Design and Structural Biology Study of Novel Nonpeptide Inhibitors of SARS-CoV Main ProteaseLu, IL; Mahindroo, N; Liang, PH ; Peng, YH; Kuo, CJ; Tsai, KC; Hsieh, HP; Chao, YS; Wu, SYJ Med Chem 49, 5154-5161
542006The critical roles of polyamines in regulating ColE7 production and restricting ColE7 uptake of the colicin producing Escherichia coliPan, YH; Liao, CC; Kuo, CC; Duan, KJ; Liang, PH ; Yuan, HS ; Hu, ST; Chak, KFJournal of Biological Chemistry 281(19), 13083-13091
552005Crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate, and farnesyl thiopyrophosphate: roles of the metal ion and conserved residues in catalysisGuo, RT; Ko, TP; Chen, AP; Kuo, CJ; Wang, AHJ ; Liang, PH Journal of Biological Chemistry 280(21), 20762-20774
562005Homodimeric hexaprenyl pyrophosphate synthase from the thermoacidophilic crenarchaeon Sulfolobus solfataricus displays asymmetric subunit structures.Sun, HY; Ko, TP; Kuo, CJ; Guo, RT; Chou, CC; Liang, PH ; Wang, AHJ Journal of Bacteriology 187(23), 8137-8148
572005Substrate and product specificities of cis-type undecaprenyl pyrophosphate synthase.Chen, AP; Chang, SY; Lin, YC; Sun, YS; Chen, CT; Wang, AHJ ; Liang, PH The Biochemical journal 386(Pt 1), 169-176
582005A novel substrate binding mode revealed by the site-directed mutagenesis studies of E. coli octaprenyl pyrophosphate synthaseKuo, CJ; Guo, RT; Li, SC; Chang, KM; Wang, AHJ ; Liang, PH Biochemistry submitted
592005Mechanism of the maturation process of SARS-CoV 3CL proteaseHsu, MF; Kuo, CJ; Chang, KT; Chang, HC; Chou, CC; Ko, TP; Shr, HL; Chang, GG; Wang, AHJ ; Liang, PH Journal of Biological Chemistry 280(35), 31257-31266
602005Discovery of Potent Anilide Inhibitors against the Severe Acute Respiratory Syndrome 3CL ProteaseShie, JJ; Fang, JM; Kuo, CJ; Kuo, TH; Liang, PH ; Huang, HJ; Yang, WB ; Lin, CH ; Chen, JL; Wu, YT; Wong, CH Journal of Medicinal Chemistry 48(13), 4469-4473
612005Inhibition of SARS-CoV 3C-like Protease Activity by Theaflavin-3,3′-digallate (TF3)Chen, CN; Lin, CP; Huang, KK; Chen, WC; Hsieh, HP; Liang, PH ; Hsu, JTEvid Based Complement Alternat Med 2(2), 209-215
622005Inhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic alpha,beta-unsaturated esters.Shie, JJ; Fang, JM; Kuo, TH; Kuo, CJ; Liang, PH ; Huang, HJ; Wu, YT; Jan, JT; Cheng, YS; Wong, CHBIOORGANIC & MEDICINAL CHEMISTRY 13, 5240-5252
632004Substrate binding mode and reaction mechanism of undecaprenyl pyrophosphate synthase deduced from crystallographic studiesChang, SY; Ko, TP; Chen, AP; Wang, AHJ ; Liang, PH Protein Science 13(4), 971-978
642004Small molecules targeting severe acute respiratory syndrome human coronavirusWu, C. Y.; Jan, J. T. ; Ma, S. H.; Kuo, C. J.; Juan, H. F.; Cheng, Y. S.; Hsu, H. H.; Huang, H. C.; Wu, D.; Brik, A.; Liang, F. S.; Liu, R. S.; Fang, J. M.; Chen, S. T. ; Liang, P. H. ; Wong, C. H. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 101(27), 10012-10017
652004DNA Binding and Degradation by the HNH Protein ColE7Hsia, K. C.; Chak, K. F.; Liang, P. H. ; Cheng, Y. S.; Ku, W. Y.; Yuan, H. S. Structure 12(2), 205-214
662004Crystal structure of octaprenyl pyrophosphate synthase from hyperthermophilic Thermotoga maritima and mechanism of product chain length determinationGuo, RT; Kuo, CJ; Chou, CC; Ko, TP; Shr, HL; Liang, PH ; Wang, AHJ The Journal of biological chemistry 279(6), 4903-4912
672004A molecular ruler for chain elongation catalyzed by octaprenyl pyrophosphate synthase and its structure-based engineering to produce unprecedented long chain trans-prenyl productsGuo, RT; Kuo, CJ; Ko, TP; Chou, CC; Liang, PH ; Wang, AHJ Biochemistry 43(24), 7678-7686
682004In vitro modification of human centromere protein CENP-C fragments by small ubiquitin-like modifier (SUMO) protein: definitive identification of the modification sites by tandem mass spectrometry analysis of the isopeptides.Chung, TL; Hsiao, HH; Yeh, YY; Shia, HL; Chen, YL; Liang, PH ; Wang, AH ; Khoo, KH ; Shoei-Lung, Li SThe Journal of biological chemistry 279(38), 39653-39662
692004Evaluation of metal-conjugated compounds as inhibitors of 3CL protease of SARS-CoVHsu, JT; Kuo, CJ; Hsieh, HP; Wang, YC; Huang, KK; Lin, CP; Huang, PF; Chen, X; Liang, PH FEBS Lett 574, 116-120
702004Involvement of colicin in the limited protection of the colicin producing cells against bacteriophageLin, YH; Liao, CC; Liang, PH ; Yuan, HS ; Chak, KFBiochemical and Biophysical Research Communications 318(1), 81-87
712004Purification and characterization of human prolyl dipeptidase DPP8 in Sf9 insect cellsChen, YS; Chien, CH; Goparaju, CM; Hsu, JT; Liang, PH ; Chen, XProtein Expr Purif 35, 142-146
722004One site mutation disrupts dimer formation in human DPP-IV proteinsChien, CH; Huang, LH; Chou, CY; Chen, YS; Han, YS; Chang, GG; Liang, PH ; Chen, XJ Biol Chem 279, 52338-52345
732004Characterization of SARS main protease and inhibitor assay using a fluorogenic substrateKuo, CJ; Chi, YH; Hsu, JT; Liang, PH Biochem Biophys Res Commun 318, 862-867
742003Identification of the active conformation and the importance of length of the flexible loop 72-83 in regulating the conformational change of undecaprenyl pyrophosphate synthaseChang, SY; Chen, YK; Wang, AHJ ; Liang, PH Biochemistry 42(49), 14452-14459
752003Catalytic mechanism revealed by the crystal structure of undecaprenyl pyrophosphate synthase in complex with sulfate, magnesium, and tritonChang, SY; Ko, TP; Liang, PH ; Wang, AHJ The Journal of biological chemistry 278(31), 29298-29307
762003Preliminary X-ray diffraction analysis of octaprenyl pyrophosphate synthase crystals from Thermotoga maritima and Escherichia coli.Guo, RT; Ko, TP; Chou, CC; Shr, HL; Chu, HM; Tsai, YH; Liang, PH ; Wang, AHJ ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY D59, 2265-2268
772003Probing electrostatic channeling in protozoal bifunctional thymidylate synthase-dihydrofolate reductase using site-directed mutagenesisAtreya, CE; Johnson, EF; Williamson, J; Chang, SY; Liang, PH ; Anderson, KSJ Biol Chem 278, 28901-28911
782002Characterization of the L399P and R447G mutants of hsc70: the decrease in refolding activity is correlated with an increase in the rate of substrate dissociationHu, S. M.; Liang, P. H. ; Hsiao, C. D. ; Wang, C. Arch Biochem Biophys 407(1), 135-141
792002Probing the Conformational Change of Escherichia coliUndecaprenyl Pyrophosphate Synthase during Catalysis Using an Inhibitor and Tryptophan MutantsChen, YH; Chen, AP; Chen, CT; Wang, AHJ ; Liang, PH The Journal of biological chemistry 277(9), 7369-76
802002Structure, mechanism and function of prenyltransferases.Liang, PH ; Ko, TP; Wang, AHJ EUROPEAN JOURNAL OF BIOCHEMISTRY 269(14), 3339-3354
812002Reaction kinetic pathway of the recombinant octaprenyl pyrophosphate synthase from Thermotoga maritima: how is it different from that of the mesophilic enzymeKuo, TH; Liang, PH Biochimica et Biophysica Acta-Proteins and Proteomics 1599, 125-133
822002Insight into the activation mechanism of Escherichia coli octaprenyl pyrophosphate synthase derived from pre-steady-state kinetic analysisPan, JJ; Kuo, TH; Chen, YK; Yang, LW; Liang, PH BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY 1594, 64-73
832002The zinc ion in the HNH motif of the endonuclease domain of colicin E7 is not required for DNA binding but is essential for DNA hydrolysisKu, WY; Liu, YW; Hsu, YC; Liao, CC; Liang, PH ; Yuan, HS ; Chak, KFNucleic Acids Research 30(7), 1670-1678
842001Processing of DNase domain during translocation of colicin E7 across the membrane of Escherichia coliLiao, CC; Hsiao, KC; Liu, YW; Leng, PH ; Yuen, HS ; Chak, KFBiochemical and Biophysical Research Communications 284(3), 556-562
852001Mechanism of Product Chain Length Determination and the Role of a Flexible Loop in Escherichia coliUndecaprenyl-pyrophosphate Synthase CatalysisKo, TP; Chen, YK; Robinson, H; Tsai, PC; Gao, YG; Chen, AP; Wang, AHJ ; Liang, PH The Journal of biological chemistry 276(50), 47474-47482
862001Refolding and characterization of a yeast dehydrodolichyl diphosphate synthase overexpressed in Escherichia coliChang, SY; Tsai, PC; Tseng, CS; Liang, PH Protein Expr Purif 23, 432-439
872001Steady-state kinetic characterization of substrates and metal-ion specificities of the full-length and N-terminally truncated recombinant human methionine aminopeptidases (type 2)Yang, G; Kirkpatrick, RB; Ho, T; Zhang, GF; Liang, PH ; Johanson, KO; Casper, DJ; Doyle, ML; Marino, JP; Thompson, SK; Chen, W; Tew, DG; Meek, TDBiochemistry 40, 10645-10654
882000Effect of site-directed mutagenesis of the conserved aspartate and glutamate on E. coli undecaprenyl pyrophosphate synthase catalysisPan, JJ; Yang, LW; Liang, PH Biochemistry 39, 13856-13861
892000Raman difference spectroscopic studies of dithiobenzoyl substrate and product analogs binding to the enzyme dehalogenase:ppi-electron polarization is prevented by the C=O to C=S substitution.Dong, J; Luo, LS; Liang, PH ; Dunaway-Mariano, D; Carey, PRJOURNAL OF RAMAN SPECTROSCOPY 31, 365-371
902000Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionalityLee, D; Long, SA; Adams, JL; Chan, G; Vaidya, KS; Francis, TA; Kikly, K; Winkler, JD; Sung, CM; Debouck, C; Richardson, S; Levy, MA; DeWolf, WE; Keller, PM; Tomaszek, T; Head, MS; Ryan, MD; Haltiwanger, RC; Liang, PH ; Janson, CA; McDevitt, PJ; Johanson, K; Concha, NO; Chan, W; Abdel-Meguid, SS; Badger, AM; Lark, MW; Nadeau, DP; Suva, LJ; Gowen, M; Nuttall, MEJ Biol Chem 275, 16007-16014
912000Product distribution and pre-steady-state kinetic analysis of Escherichia coli undecaprenyl pyrophosphate synthase reactionPan, JJ; Chiou, ST; Liang, PH Biochemistry 39, 10936-10942
921999Crystallographic Studies of Phosphonat-Based alpha-reaction transition-State Analogues Complexed to Tryptophan SynthaseSachpatzidis, A; Dealwis, C; Lubetsky, JB; Liang, PH ; Anderson, KS; Lolis, EBiochemistry 38, 12665-12674
931998Kinetic Reaction Scheme for the Dihydrofolate Reductase Domain of the Bifunctional Thymidylate Synthase - Dihydrofolate Reductase from Leishmania MajorLiang, PH ; Anderson, KSBiochemistry 37, 12206-12212
941998Loop Closure and Intersubunit Communication in Tryptophan SynthaseSchneider, TR; Gerhardt, E; Lee, M; Liang, PH ; Anderson, KS; Schlichting, IBiochemistry 37, 5394-5406
951998Site-Directed Mutagenesis Probing the Catalytic Role of Arginines 165 and 166 of Human Cytomegalovirus ProteaseLiang, PH ; Brun, KA; Feild, JA; O’Donnell, K; Doyle, ML; Green, SM; Baker, AE; Blackburn, MN; Abdel-Meguid, SSBiochemistry 37, 5923-5929
961998Leishmania Major Pteridine Reductase 1 Belongs to the Short Chain Dehydrogenase Family: Stereochemical and Kinetic EvidenceLuba, J; Nare, B; Liang, PH ; Anderson, KS; Beverley, SM; Hardy, LWBiochemistry 37, 4093-4104
971998Catalytic Mechanism of Kdo8P Synthase: Transient Kinetic Studies and Evaluation of a Putative Reaction IntermediateLiang, PH ; Lewis, J; Anderson, KS; Kohen, A; D’Souza, FW; Benenson, Y; Baasov, TBiochemistry 37, 16390-16399
981998Substrate Channeling and Domain-Domain Interactions in Bifunctional Thymidylate Synthase - Dihydrofolate ReductaseLiang, PH ; Anderson, KSBiochemistry 37, 12195-12205
991997Catalytic Mechanism of KDO8P Synthase, Pre-Steady-State Kinetic Analysis Using Rapid Chemical Quench Flow MethodsLiang, PH ; Kohen, A; Baasov, T; Anderson, KSBioorg Med Chem Lett 7, 2463-2468
1001997Pre-Steady-State Kinetic Analysis of the Trichodiene Synthase Reaction PathwayCane, DE; Chiu, HT; Liang, PH ; Anderson, KSBiochemistry 36, 8332-8339
1011995Evidence for Electrophilic Catalysis in the 4-Chlorobenzoyl-CoA Dehalogenase Reaction: UV, Raman and C-13 NMR Spectral Studies of Dehalogenase Complexes of Benzoyl-CoA AdductsTaylor, KL; Liu, RQ; Liang, PH ; Price, J; Dunaway-Mariano, D; Tonge, PJ; Clarkson, J; Carey, PRBiochemistry 34, 13881-13888
1021995Transient State Kinetic Analysis of the Chemical Intermediate Formed in the Enzymatic Dehalogenation of 4-Chlorobenzoyl Coenzyme ALiu, RQ; Liang, PH ; Scholten, J; Dunaway-mariano, DJ Am Chem Soc 117, 5003-5004
1031994Evidence for Nucleophilic Catalysis in the Aromatic Substitution Reaction Catalyzed by (4-Chlorobenzoyl) coenzyme A dehalogenaseYang, G; Liang, PH ; Dunaway-Mariano, DBiochemistry 33, 8527-8531
1041993Specificity of 4-chlorobenzoate-Coenzyme A dehalogenase catalyzed dehalogenation of halogenated aromaticsLiang, PH ; Yang, G; Dunaway-Mariano, DBiochemistry 32, 12245-12250
1051992Ancestry of the 4-chlorobenzoate dehalogenase: Analysis of amino acid sequence identities among families of acyl: adenyl ligase, enoyl-CoA hydratase/isomerase, and acyl-CoA thioesteraseBabbitt, PC; Kenyon, GL; Martin, BM; Charest, H; Slyvestre, M; Scholten, JD; Chang, KH; Liang, PH ; Dunaway-Mariano, DBiochemistry 31, 5594-5604
1061992Isolation and characterization of the three polypeptide components of 4-chlorobenzoate dehalogenase from Pseudomonas sp. Strain CBS-3Chang, KH; Liang, PH ; Beck, W; Scholten, JD; Dunaway-Mariano, DBiochemistry 31, 5605-5610