Publications

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Issue DateTitleAuthor(s)RelationscopusWOSFulltext/Archive link
1201801.故院長講座. 吳大猷院長講座「基因科技與抗老化研究」沈哲鯤 
22012Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43Wang, I. -F.; Guo, B. -S.; Liu, Y. -C.; Wu, C. -C.; Yang, C. -C.; Tsai, K. -J.; Shen, C. -K. J. Proc Natl Acad Sci USA 109, 15024-15029
32012The self-interaction of native TDP-43 C-terminus Inhibits; Its degradation and contributes to early proteinopathiesWang, I. -F.; Chang, H. -Y.; Hou, S. -C.; Liou, G. -G.; Way, T. -D.; Shen, C. -K. J. Nature Commun. 3, 766
42012TDP-43 Regulates The Mammalian Spinogenesis Through Translational Repression of Rac1Majumder, P.; Tsai, K. -J.; Wu, C. -C.; Chen, Y. -T.; Bose, J. K.; Cheng, W. -C.; Fang, Y. -H.; Chen, Y. -L.; Lien, C. -C.; Cheng, S. -J.; Shen, C. -K. J. Acta Neuropathologica 124, 231-245
52012The Mammalian de novo DNA Methyltransferases DNMT3A and DNMT3B Are Also DNA 5-Hydroxymethyl Cytosine DehydroxymethylasesChen, C. -C.; Wang, K. -Y.; Shen, C. -K. J. J. Biol. Chem. 287, 33116-33121
62012Targeted Depletion of TDP-43 Expression in the Spinal Cord Motor Neurons Leads to the Development of ALS-like Phenotypes in MiceWu, L. -S.; Cheng, W. -C.; Shen, C. -K. J. J. Biol. Chem. 287, 27335-27344
72011Regulation of autophagy by the neuropathological protein TDP-43Bose, J. K.; Huang, C. -C.; Shen, C. -K. J. Journal of Biological Chemistry 286, 44441-44448
82011Neuronal Function and Dysfunction of Drosophila dTDPLin, M. -J.; Cheng, C. -W.; Shen, C. -K. J. PLoS ONE 6(6), e20371
92010Elevated expression of TDP-43 in the forebrain of mice is sufficient to cause neurological and pathological phenotypes mimicking FTLD-UTsai, Kuen-Jer; Yang, Chun-Hung; Fang, Yen-Hsin; Cho, Kuan-Hung; Chien, Wei-Lin; Wang, Wei-Ting; Wu, Tzu-Wei; Lin, Ching-Po; Fu, Wen-Mei; Shen, Che-Kun James The Journal of Experimental Medicine 207(8), 1661-1673
102010Developmental silencing of the humanζglobin gene expression is mediated by the transcriptional repressor RREB1Chen, R. -L.; Chou, Y. -C.; Lan, Y. -J.; Huang, T. -S.; Shen, C. -K. J. Journal of Biological Chemistry 285, 10189-10197
112010JNK-Mediated Turn-over and Stabilization of the Transcription Factor p45/NF-E2 During Differentiation of Murine Erythroleukemia CellsLee, T. L.; Shyu, Y. C.; Hsu, P. C.; Wen, S. C.; Hsiao, W. Y.; Chang, C. W.; Tsai, M. D.; Shen, C. -K. J. Proceedings of the national academy of sciences of the United States of America 107, 52-57
122009Ankrd17, an ubiquitously expressed ankyrin factor, is essential for the vascular integrity during embryogenesisHou, Shin-Chen; Chan, Li-Wei; Chou, Yu-Chi ; Su, Ching-Yuan; Chen, Xin; Shih, Yen-Ling; Tsai, Pei-Chun; Shen, C. -K. James ; Yan, Yu-Ting FEBS Letters 583(17), 2765-2771
132009Structural insights into TDP-43 in nucleic-acid binding and domain interactionsKuo, P H; Doudeva, L. G.; Wang, Y. -T.; Shen, C. -K. J. ; Yuan, H. S. Nucleic Acids Research 37(6), 1799-1808
142009Asymmetric expression patterns of brain transthyretin in normal mice and a transgenic mouse model of Alzheimer's diseaseTsai, K. -J.; Yang, C. -H.; Lee, P. -C.; Wang, W. -T.; Chiu, M. -J.; Shen, C. -K. J. Neuroscience 159, 638-46
152009TDP-43, A Neuro-Pathosignature Factor, Is Essential for Early Mouse Embryogenesis.Wu, L. S.; Cheng, W. C.; Hou, S. C.; Yan, Y. T.; Jiang, S. T.; Shen, C. K. J. Genesis 48(1), 56-62
162008TDP-43 overexpression enhances exon 7 inclusion during the survival of motor neuron pre-mRNA splicingBose, J. K.; Wang, I. -F.; Li, H.; Tarn, W. -Y.; Shen, C. -K. J. J Biol Chem 283, 28852-28859
172008TDP-43: an emerging new player in neurodegenerative diseasesWang, I. -F.; Wu, L. -S.; Shen, C. -K. J. Trends Mol Med. 14, 479-485
182008TDP -43, the signature protein of FTLD-U, is a neuronal activity-responsive factorWang, I. F.; Wu, L. S.; Chang, H. Y.; Chiou, G. Y.; Shen, C. K. J. J. Neurochem 105, 797-806
192007Epigenetic regulation of the Drosophila chromosome 4 by the histone H3K9 methyltransferase dSETDB1Tzeng, T. Y.; Lee, C. H.; Chan, L. W.; Shen, C. K. J. Proceedings of the national academy of sciences of the United States of America 104, 12691-12696
202007G-CSF rescues the memory impairment of animal models of Alzheimer’s diseaseTsai, K. J.; Tsai, Y. C.; Shen, C. K. J. J Exp Med 204, 1273-1280
212007Rate of Evolution in Brain-Expressed Genes in Humans and Other PrimatesWang, H. Y.; Chien, H. C.; Osada, N.; Hashimoto, K.; Sugano, S.; Gojobori, T.; Chou, C. K.; Tsai, S. F.; Tang, H.; Wu, C. I.; Shen, C. K. J. PLOS Biology 5(2), e13
222006Actin-based modeling of a transcriptionally competent nuclear substrcuture induced by transcription inhibitionWang, I. F.; Chang, H. Y.; Shen, C. K. J. Exp Cell Res 312, 3796-3807
232006Proliferin enhances microvilli formation and cell growth of neuroblastoma cellsWang, J. W.; Jiang, Y. N.; Huang, C. Y.; Huang, P. Y.; Huang, M. C.; Cheng, W. T. K.; Shen, C. K. J. ; Ju, Y. T.Neuroscience Research 56, 80-90
242005Substitution rate and structural divergence of 5'UTR evolution:comparative analysis between human and cynomolgus monkey cDNAsOsada, N.; Hirata, M.; Tanuma, R.; Kusuda, J.; Hida, M.; Suzuki, Y.; Sugano, S.; Gojobori, T.; Shen, C. K. J. ; Wu, C. I.; Hashimoto, K.Mol Biol Evol 22, 1976-1982
252005Sumoylation of p45/NF-E2: nuclear positioning and transcriptional activation of the mammalian beta-like globin gene locusShyu, Y. C.; Lee, T. L.; Ting, C. Y.; Wen, S. C.; Hsieh, L. J.; Li, Y. C.; Hwang, J. L.; Lin, C. C.; Shen, C. K. J. Mol Cell Biol 25, 10365-10378
262005DNA methyltransferase dDnmt2 and Drosophila longevityLin, M. J.; Tang, L. Y.; Reddy, M. N.; Shen, C. K. J. J Biol Chem 280, 861-864
272004Structural diversity and functional implications of the eukaryotic TDP gene familyWang, H. Y.; Wang, I. F.; Bose, J.; Shen, C. K. J. Genomics 83, 130-139
282004DNA methyltransferase Dnmt1 and mismatch repairWang, K. Y.; Shen, C. K. J. Oncogene 23, 7898-7902
292003A candidate gene for Drosophila genome methylationReddy, M. Narsa; Tang, L. Y.; Lee, T. L.; Shen, C. K. J. Oncogene 22, 6301-6303
302003The eukaryotic DNMT2 genes encode a new class of cytosine-5 DNA methyltransferasesTang, L. Y.; Reddy, M. N.; Rasheva, V.; Lee, T. L.; Lin, M. J.; Hung, M. S.; Shen, C. K. J. J Biol Chem 278, 33613-33616
312003Rapidly evolving genes in human. I. The glycophorins and their possible role in evading malaria parasites.Wang, H. Y.; Tang, H.; Shen, C. K. J. ; Wu, C. I.Mol Biol Evol 20, 1795-1804
322003Erythroid gene suppression by NF-kappa BLiu, J. J.; Hou, S. C.; Shen, C. K. J. J Biol Chem 278, 19534-19540
332003Eukaryotic methyl-CpG-binding domain proteins and chromatin modificationHung, M. S.; Shen, C. K. J. Eukaryot Cell 2, 841-846
342002Higher order arrangement of the eukaryotic nuclear bodiesWang, I. F.; Reddy, N. M.; Shen, C. K. J. Proceedings of the national academy of sciences of the United States of America 99, 13583-13588
352002NAPP2, a peroxisomal membrane protein, is also a transcriptional corepressorGavva, N. R.; Wen, S. C.; Daftari, P.; Moniwa, M.; Yang, W. M.; Yang-Feng, L. P.; Seto, E.; Davie, J. R.; Shen, C. K. J. Genomics 79, 423-431
362001Sharing duties in the familyShen, C. K. J. Genome Res 11, 1615
372001Human ITCH is a coregulator of the hematopoietic transcription factor NF-E2Chen, X.; Wen, S.; Fukuda, M. N.; Gavva, N. R.; Hsu, D.; Akama, T. O.; Yang-Feng, T.; Shen, C. K. J. Genomics 73, 238-241
382000Transcriptional repression by Drosophila methyl-CpG-binding proteinsRoder, K.; Hung, M. S.; Lee, T. L.; Lin, T. Y.; Xiao, H.; Isobe, K. I.; Juang, J. L.; Shen, C. K. J. Mol Cell Biol 20, 7401-7409
392000One-codon alternative splicing of the CpG MTase Dnmt1 transcript in mouse somatic cellsLin, M. J.; Lee, T. L.; Hsu, D. W.; Shen, C. K. J. FEBS Lett 469, 101-104
402000Loading of DNA-binding factors to an erythroid enhancerWen, S. C.; Roder, K.; Hu, K. Y.; Rombel, I.; Gavva, N. R.; Daftari, P.; Kuo, Y. Y.; Wang, C. ; Shen, C. K. J. Molecular and Cellular Biology 20(6), 1993-2003
411999Two major forms of DNA (cytosine-5) methyltransferase in human somatic tissuesHsu, D. W.; Lin, M. J.; Lee, T. L.; Wen, S. C.; Chen, X.; Shen, C. K. J. Proceedings of the national academy of sciences of the United States of America 96, 9751-9756
421999Drosophila proteins related to vertebrate DNA (5-cytosine) methyltransferasesHung, M. S.; Karthikeyan, N.; Huang, B.; Koo, H. C.; Kiger, J.; Shen, C. K. J. Proceedings of the national academy of sciences of the United States of America 96, 11940-11945
431998Derepression of human embryonic zeta-globin promoter by a locus-control region sequenceHuang, B. L.; Fan-Chiang, I. R.; Wen, S. C.; Koo, H. C.; Kao, W. Y.; Gavva, N. R.; Shen, C. K. J. Proceedings of the national academy of sciences of the United States of America 95, 14669-14674
441988Structure and expression of the human theta 1 globin geneHsu, S. L.; Marks, J.; Shaw, J. P.; Tam, M.; Higgs, D. R.; Shen, C. C.; Shen, C. K. J. Nature 331, 94-96