Publications

Results 1-67 of 67 (Search time: 0.003 seconds).

Issue DateTitleAuthor(s)RelationscopusWOSFulltext/Archive link
12022A critical overview of current progress for COVID-19: development of vaccines, antiviral drugs, and therapeutic antibodiesKumari, Monika; Lu, Ruei-Min ; Li, Mu-Chun; Huang, Jhih-Liang; Hsu, Fu-Fei; Ko, Shih-Han; Ke, Feng-Yi; Su, Shih-Chieh; Liang, Kang-Hao; Yuan, Joyce Pei-Yi; Chiang, Hsiao-Ling; Sun, Cheng-Pu; Lee, I.-Jung; Li, Wen-Shan ; Hsieh, Hsing-Pang ; Tao, Mi-Hua ; Wu, Han-Chung Journal of Biomedical Science 29(1), 68
22022Heteronemin and Tetrac Induce Anti-Proliferation by Blocking EGFR-Mediated Signaling in Colorectal Cancer CellsUnson, Sukanya; Chang, Tung-Cheng; Yang, Yung-Ning; Wang, Shwu-Huey; Huang, Chi-Hung; Crawford, Dana R.; Huang, Haw-Ming; Li, Zi-Lin; Lin, Hung-Yun; Whang-Peng, Jacqueline; Wang, Kuan; Davis, Paul J.; Li, Wen-Shan Marine Drugs 20(8), 482
32022Heteronemin and tetrac derivatives suppress non-small cell lung cancer growth via ERK1/2 inhibitionChung, CC; Huang, TY; Chu, HR; De Luca, R; Candelotti, E; Huang, CH; Yang, YSH; Incerpi, S; Pedersen, JZ; Lin, CY; Huang, HM; Lee, SY; Li, ZL; ChangOu, CA; Li, WS ; Davis, PJ; Lin, HY; Whang-Peng, J; Wang, KFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association 161, 112850
42021Design, synthesis, and characterization of oxadiazolopyrazine analogs with application as anticancer agentsChen, Wei‐Chia; Chen, Chia‐Ling; Chang, Tzu‐Ting; Hsieh, Feng‐Chun; Chen, Wei‐Sheng; Li, Wen‐Shan Journal of the Chinese Chemical Society 69(2), 375-387
52021Sialyltransferase Inhibitors for the Treatment of Cancer Metastasis: Current Challenges and Future PerspectivesSer John Lynon P. Perez; Chih-Wei Fu; Wen-Shan Li Molecules 26(18), 5673
62021Sialyltransferase Inhibitors Suppress Breast Cancer MetastasisChih-Wei Fu; Han-En Tsai; Wei-Sheng Chen; Tzu-Ting Chang; Chia-Ling Chen; Pei-Wen Hsiao ; Wen-Shan Li JOURNAL OF MEDICINAL CHEMISTRY 64(1), 527-542
72020Antiangiogenic Effect of Isomalyngamide A Riboside CY01 in Breast Cancer Cells via Inhibition of Migration, Tube Formation and pVEGFR2/pAKT SignalsChing-Ying Shih; Tzu-Ting Chang; Chia-Ling Chen; Wen-Shan Li Anti-Cancer Agents in Medicinal Chemistry 20(3), 386-399
82020Benzenesulfonamide Derivatives as Calcium/Calmodulin-Dependent Protein Kinase Inhibitors and Antiviral Agents against Dengue and Zika Virus InfectionsChen, Wei-Chia; Simanjuntak, Yogy; Chu, Li-Wei; Ping, Yueh-Hsin; Lee, Yi-Ling; Lin, Yi-Ling ; Li, Wen-Shan Journal of Medicinal Chemistry 63(3), 1313-1327
92020Oxidative trimerization of indoles via water-assisted visible-light photoredox catalysis and the study of their anti-cancer activitiesCheng, Li-Ting; Luo, Sheng-Qi; Hong, Bor-Cherng; Chen, Chia-Ling; Li, Wen-Shan ; Lee, Gene-HsiangOrganic & Biomolecular Chemistry 18(32), 6247-6252
102019Bishomolithocholic acid: A Unique Template for Human Sialyltransferase Inhibitor, Optimized to Suppress Cancer MetastasisZih-Fan Hsu; Chia-Ling Chen; Tzu-Ting Chang; Wen-Shan Li 
112019Liposomal irinotecan for treatment of colorectal cancer in a preclinical model.Huang, J. R.; Lee, M. H.; Li, W. S. ; Wu, H. C. Cancers (Basel) 11(3), 281
122018Nano-Diamino-Tetrac (NDAT) Enhances Resveratrol-Induced Antiproliferation by Action on the RRM2 Pathway in Colorectal CancersAndré Wendindondé Nana; Szu Yuan Wu; Yu-Chen SH Yang; Yu-Tang Chin; Tsai-Mu Cheng; Yih Ho; Wen-Shan Li ; Yu-Min Liao; Yi-Ru Chen; Ya-Jung Shih; Yun-Ru Liu; Jens Pedersen; Sandra Incerpi; Aleck Hercbergs; Leroy F. Liu; Jacqueline Whang-Peng; Paul J. Davis; Hung-Yun LinHormones and Cancer 9, 349-360
132018Liposomal Paclitaxel Induces Fewer Hematopoietic and Cardiovascular Complications than Bioequivalent Doses of TaxolShih-Ting Huang; Yi‑Ping Wang; Yen-Hui Chen ; Chin-Tarng Lin; Wen-Shan Li ; Han-Chung Wu International Journal of Oncology 53(3), 1105-1117
142018Aggregation‐induced emission enhancement of anthracene‐derived Schiff base compounds and their application as a sensor for bovine serum albumin and optical cell imagingSimon Densil; Chien-Huei Chang; Chia-Ling Chen; Alagarsamy Mathavan; Arumugam Ramdass; Veerasamy Sathish; Pounraj Thanasekaran; Wen-Shan Li ; Seenivasan RajagopalLuminescence 33(4), 780-789
152018Exploration and Optimization of Cyclohexane-based Tetraindoles Exerting Antitumor Activity against Cancer cell LinesHung-Chi Yen; Chia-Ling Chen; Wen-Shan Li 
162018Tetrac downregulates β-catenin and HMGA2 to promote the effect of resveratrol in colon cancerAndré Wendindondé Nana; Yu-Tang Chin; Chi-Yu Lin; Yih Ho; Ya-Jung Shih; Yi-Ru Chen; Chun A. Changou; Jens Z. Pedersen; Sandra Incerpi; Leroy F. Liu; Jacqueline Whang-Peng; Earl Fu; Wen-Shan Li ; Shaker A Mousa; Hung-Yun Lin; Paul J. DavisEndocrine-Related Cancer 25(3), 279-293
172018Investigation of the proton relay system operative in human cystosolic aminopeptidase PHui-Chuan Chang; Camy C.-H. Kung; Tzu-Ting Chang; Shu-Chuan Jao; Yu-Ting Hsu; Wen-Shan Li PLoS One 13(1):e0190816
182017Design, screening, synthesis and evaluation of the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (IDO1) inhibitorsWen-Shan Li ; Chien-Huei Chang; Chia-Ling Chen; Tzu-Ting Chang; Shu-Chuan Jao
192017Aggregation induced emission enhancement (AIEE) characteristics of quinoline based compound — A versatile fluorescent probe for pH, Fe(III) ion, BSA binding and optical cell imagingIrulappan Manikandan; Chien-Huei Chang; Chia-Ling Chen; Veerasamy Sathish; Wen-Shan Li ; Mahalingam MalathiSpectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 182, 58-66
202017Discovery, Design, and Optimization of New Aromatic-Nitrogen Conjugates against Dengue Virus InfectionWei-Chia Chen; Yogy Simanjuntak; Yi-Ling Lin; Wen-Shan Li 
212017Glycosylation of Isomalynamide A Analogs Triggers the Anti-migratory Activity and Antiangiogenesis EffectChing-Ying Shih; Tzu-Ting Chang; Chia-Ling; Chen; Wen-Shan Li 
222017Oxadiazolopyrazine derivatives: Synthesis and anticancer mechanism investigationWen-Shan Li ; Wei-Chia Chen
232017Synthesis Of Biologically Active Bis(Indolyl)Methane Derivatives by Bisindole Alkylation of Tetrahydroisoquinolines with Visible-Light Induced Ring-Opening FragmentationChia-Chueng Chen; Bor-Cherng Hong; Wen-Shan Li ; Tzu-Ting Chang; Gene-Hsiang LeeASIAN JOURNAL OF CHEMISTRY 6(4), 426-431
242017Elevation of β-galactoside α2,6-sialyltransferase 1 in a fructose-responsive manner promotes pancreatic cancer metastasisHsieh, C.C.; I.M. Shyu; W.Y. Liao; T.H. Chen; S.E. Wang; P.C. Lu; P.Y. Lin; Y.B. Chen; W.Y. Mao; H.Y. Han; M. Hsiao; W.B. Yang; W.S. Li ; Y.P. Sher; C.N. Shen Oncotarget 8(5), 7691-7709
252016SYNTHESIS AND ANTICANCER ACTIVITY EVALUATION OF OXADIAZOLOPYRAZINE DERIVATIVESWei-Chia Chen; Chih-Wei Fu; Chia-Ling Chen; Wen-Shan Li 
262016INVESTIGATE THE ROLE OF SIALYLTRANSFERASE INHIBITOR ON MDA-MB-231 BREAST CANCER CELLS IN VITRO AND IN VIVOHan-En Tsai; Chih-Wei Fu; Tzu-Ting Chang; Chia-Ling Chen; Wen-Shan Li 
272016Synthesis of Amino Acid-comprising Sialyltransferase Inhibitors and Their Antimetastatic Activities against Human Breast Cancer CellsChih-Wei Fu; Kai-Hsuan Chang; Ya Ching Jen; Tzu Ting Chang; Wen-Shan Li JOURNAL OF THE CHINESE CHEMICAL SOCIETY 63, 171–180
282016Nature-inspired design of tetraindoles: Optimization of the core structure and evaluation of structure–activity relationshipAbdu-Allah, HH; Huang, ST; Chang, TT; Chen, CL; Wu, HC ; Li, WS Bioorganic & medicinal chemistry letters 26(18), 4497-4503
292016Synthesis of B- and C-ring-modified lithocholic acid analogues as potential sialyltransferase inhibitors.Abdu-Allah, HH; Chang, TT; Li, WS Steroids 112, 54-61
302015“ABX” Analogs: Fluorescent Dyes for Live Cell Imaging and Biological ApplicationsWen-Shan Li ; Shivaji V. More; Mingxin Liu; Mohammad Hassam; Wan-June Tsai; Chien-Huei Chang; Chia-Ling Chen
312015Anticancer efficacy of unique pyridine-based tetraindolesChih-Wei Fu; Yun-Jung Hsieh; Tzu Ting Chang; Chia-Ling Chen; Cheng-Yu Yang; Anne Liao; Pei-Wen Hsiao ; Wen-Shan Li European Journal of Medicinal Chemistry 104, 165-176
322015Copper-catalyzed Markovnikov hydration of alkynesMohammad Hassam; Wen-Shan Li TETRAHEDRON 71, 2719–2723
332014Synthetic Isomalyngamide A Analogs that Inhibit Breast Cancer MigrationWen-Shan Li ; Tzu Ting Chang; Chien-Chin Hung; Chia-Ling Chen; Shu-Chuan Jao
342014Tetraindole suppresses breast cancer growth and metastasis by reversing epithelial-mesenchymal transition state associated with up-regulation of the miR-200 familyWen-Shan Li ; Chie-Hong Wang; Chia-Ling Chen; Shu-Chuan Jao
352013Evidence for Chemical Rescue of Proton Relay System for Human Cytosolic Aminopeptidase PWen-Shan Li ; Hui-Chuan Chang; Tzu-Ting Chang; Shu-Chuan Jao
362012The novel indole compound SK228 induces apoptosis and FAK/Paxillin disruption in tumor cell lines and inhibits growth of tumor graft in the nude mouseSin-Ming Huang; Pei-Chun Hsu; Mei-Yu Chen; Wen-Shan Li ; Shivaji V. More; Kwok-Tung Lu; Yi-Ching WangInternational Journal of Cancer 131(3), 722-732
372012Synthesis and Evaluation of the Cytotoxicities of Tetraindoles: Observation that the 5-Hydroxy Tetraindole (SK228) Induces G2 Arrest and Apoptosis in Human Breast Cancer CellsWen-Shan Li ; Chie-Hong Wang; Shengkai Ko; Tzu Ting Chang; Ya Ching Jen; Ching-Fa Yao; Shivaji V. More; Shu-Chuan JaoJournal of Medicinal Chemistry 55(4), 1583-1592
382011Inhibition of Glutathione S-Transferase M1 by New Gabosine Analogues Is Essential for Overcoming Cisplatin Resistance in Lung Cancer CellsChie-Hong Wang; Ho T. Wu; Hau Man Cheng; Tien-Jui Yen; I-Hsuan Lu; Hui Chuan Chang; Shu-Chuan Jao ; Tony Kung Ming Shing; Wen-Shan Li Journal of medicinal chemistry 54(24), 8574-8581
392011Isomalyngamide A, A-1 and their analogs suppress cancer cell migration in vitroTzu Ting Chang; Shivaji V. More; I-Hsuan Lu; Jui-Ching Hsu; Ting-Ju Chen; Ya Ching Jen; Chung-Kuang Lu; Wen-Shan Li European Journal of Medicinal Chemistry 46(9), 3810-3819
402011Polyfluorinated bipyridine cisplatins manipulate cytotoxicity through the induction of S-G2/M arrest and partial intercalation mechanismTzu Ting Chang; Shivaji V. More; Norman Lu; Jyun-Wei Jhuo; Yi-Chuan Chen; Shu-Chuan Jao ; Wen-Shan Li Bioorganic & medicinal chemistry 19(16), 4887-4894
412011Preparation and Characterization of Amino-Linked Heterocyclic Carbene Palladium, Gold, and Silver Complexes and Their Use as Anticancer Agents That Act by Triggering Apoptotic Cell DeathWang, Chie-Hong; Shih, Wei-Chih; Chang, Hui Chuan; Kuo, Yi-Yin; Hung, Wen-Chun; Ong, Tiow-Gan ; Li, Wen-Shan JOURNAL OF MEDICINAL CHEMISTRY 54(14), 5245-5249
422011A novel sialyltransferase inhibitor suppresses FAK/paxillin signaling and cancer angiogenesis and metastasis pathwaysJia-Yang Chen; Yen-An Tang; Sin-Ming Huang; Hsueh-Fen Juan; Li-Wha Wu; Ying-Chieh Sun; Szu-Chi Wang; Kuan-Wei Wu; Gopula Balraj; Tzu-Ting Chang; Wen-Shan Li ; Hung-Chi Cheng; Yi-Ching WangCancer Research 71(2), 473-483
432010A novel sialyltransferase inhibitor AL10 suppresses invasion and metastasis of lung cancer cells by inhibiting integrin-mediated signalingChi-Hsiang Chiang; Chie-Hong Wang; Hui-Chiu Chang; Shivaji V. More; Wen-Shan Li ; Wen-Chun HungJournal of Cellular Physiology 223(2), 492-499
442010Synthesis and structure–activity relationships of novel furazan-3,4-diamide analogs as potent anti-cancer agentsWen-Shan Li ; Shivaji V. More; Chie-Hong Wang; Ya Ching Jen; Ching-Fa Yao; Tein-Fu Wang; Chin-Chun Hung ; Shu-Chuan Jao Bioorganic & medicinal chemistry letters 20(3), 1148-1152
452010Overcoming the drug resistance in breast cancer cells by rational design of efficient glutathione S-transferase inhibitorsWen-Shan Li ; Wing See Lam; Kung-Cheng Liu; Chie-Hong Wang; Hui Chuan Chang; Ya Ching Jen; Yu-Ting Hsu; Sachin Shivatare; Shu-Chuan Jao Organic letters 12(1), 20-23
462008Evaluation of organophosphorus chemicals-degrading enzymes: a comparison of Escherichia coli and human cytosolic aminopeptidase PHsu, YT; Su, CY; Du, HC; Jao, SC ; Li, WS Chemistry & biodiversity 5(7), 1401-1411
472008Oxidations of N-(3-Indoleethyl) Cyclic Aliphatic Amines by Horseradish Peroxidase:  The Indole Ring Binds to the Enzyme and Mediates Electron-Transfer Amine OxidationLing, KQ; Li, WS ; Sayre, LMJournal of the American Chemical Society 130(3), 933-944
482007Enzymatic and Nonenzymatic Synthesis of Glutathione Conjugates: Application to the Understanding of a Parasite's Defense System and Alternative to the Discovery of Potent Glutathione S-Transferase InhibitorsLo, WJ; Chiou, YC; Hsu, YT; Lam, WS; Chang, MY; Jao, SC ; Li, WS Bioconjugate Chemistry 18(1), 109-120
492006Synthesis and Biological Evaluation of 5′-Triazole NucleosidesLee, Lenselot; Chang, KH; Valiyev, Famil; Liuc, HJ; Li, WS Journal of the Chinese Chemical Society 53(6), 1547-1555
502006Aminopeptidase P Mediated Detoxification of Organophosphonate Analogues of Sarin: Mechanistic and Stereochemical Study at the Phosphorus Atom of the SubstrateHuang, LF; Su, BS; Jao, SC ; Liu, KT; Li, WS ChemBioChem 7(3), 506-514
512006Tyrosine 387 and arginine 404 are critical in the hydrolytic mechanism of Escherichia coli aminopeptidase P.Jao, SC ; Huang, LF; Hwang, SM; Li, WS Biochemistry 45(6), 1547-1553
522006Design of potent inhibitors for Schistosoma japonica glutathione S-transferaseJao, SC ; Chen, J; Yang, K; Li, WS Bioorganic & medicinal chemistry 14(2), 304-318
532006Lithocholic acid analogues, new and potent α-2,3-sialyltransferase inhibitorsChang, KH; Lee, L; Chen, J; Li, WS Chemical Communications 2006(6), 629-631
542006Catalytic hydrogenation of halosteroidal derivatives by bipyridine or phenanthroline complexes of copper(II) in hydrazine aqueous mediaDu, HC; Liu, KC; Li, WS Synthetic Communications 36(5), 621-630
552004Hydrolysis of organophosphate triesters by Escherichia coli aminopeptidase PS.-C. Jao; L.-F. Huang; Y. S. Tao; W.-S. Li Journal of Molecular Catalysis B: Enzymatic 27(1), 7-12
562004Synthesis of Anomeric Sulfur Analogues of CMP-Neu5Ac Containing Tethered Alkane or AreneK.-H. Chang; Y. S. Tao; W.-S. Li Synlett 2004(1), 37-40
572003Enhanced Degradation of Chemical Warfare Agents through Molecular Engineering of the Phosphotriesterase Active SiteCraig M. Hill; Wen-Shan Li ; James B. Thoden; Hazel M. Holden; Frank M. RaushelJournal of the American Chemical Society 125(30), 8990-8991
582003A selective Cu(II)/Fe(III)-mediated hydrogenation of steroidal haloalkenes in the presence of hydrazineK.-H. Chang; H.-R. Wu; M. N. Jenkins; W.-S. Li Tetrahedron Letters 44(7), 1351-1354
592002Enzymatic Synthesis of Chiral Organophosphothioates from Prochiral PrecursorsWen-Shan Li ; Yingchun Li; Craig M. Hill; Karin Lum; Frank M. RaushelJournal of the American Chemical Society 124(14), 3498-3499
602001Stereoselective Detoxification of Chiral Sarin and Soman Analogues by PhosphotriesteraseWen-Shan Li ; Karin T. Lum; Misty Chen-Goodspeed; Miguel A. Sogorb; Frank M. RaushelBioorganic & Medicinal Chemistry 9(8), 2083-2091
612001N1,N10-Ethylene-bridged high-potential flavins: synthesis, characterization, and reactivityWen-Shan Li ; Nanjing Zhang; Lawrence M. SayreTetrahedron 57(21), 4507-4522
622001Reaction of amines with N1,N10-ethylene-bridged flavinium salts: the first NMR spectroscopic evidence of C10a tetrahedral amine adductsWen-Shan Li ; Lawrence M. SayreTetrahedron 57(21), 4523-4536
632001Stereochemical Specificity of Organophosphorus Acid Anhydrolase Toward p-Nitrophenyl Analogs of Soman and SarinCraig M. Hill; Wen-Shan Li ; Tu-Chen Cheng; Joseph J. DeFrank; Frank M. RaushelBioorganic Chemistry 29(1), 27-35
642000Rationally Engineered Mutants of Phosphotriesterase for Preparative Scale Isolation of Chiral OrganophosphatesFeiyue Wu; Wen-Shan Li ; Misty Chen-Goodspeed; Miguel A. Sogorb; Frank M. RaushelJournal of the American Chemical Society 122(41), 10206-10207
652000Experimental verification of a predicted, previously unseen separation selectivity pattern in the capillary electrophoretic separation of noncharged enantiomers by octakis(2,3-diacetyl-6-sulfato)-γ-cyclodextrinWenhong Zhu; Wen-Shan Li ; Frank M. Raushel; Gyula VighElectrophoresis 21(15), 3249-3256
662000Long-Range Through-Bond Photoactivated σ Bond Cleavage in Steroids. Intramolecular Sensitized DebrominationWen-Shan Li ; Harry MorrisonOrganic Letter 2(1), 15-18
671996trans-2-Phenylcyclopropylamine is a Substrate for and Inactivator of Horseradish PeroxidaseLawrence M. Sayre; Robert T. Naismith II; Michael A. Bada; Wen-Shan Li ; Molly E. Klein; Mark D. TennantBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology 1296(2), 250-256