Publications

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Issue DateTitleAuthor(s)RelationscopusWOSFulltext/Archive link
12022Efficient strategy to design protease inhibitors: Application to enterovirus 71 2A proteaseTing Chen; Cédric Grauffel; Wei-Zen Yang; Yi-Ping Chen; Hanna S. Yuan ; Carmay Lim ACS Bio & Med Chem Au 2(4), 437-449
22021Correction: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectorsSargsyan, Karen; Lin, Chien-Chu; Chen, Ting; Grauffel, Cédric; Chen, Yi-Ping; Yang, Wei-Zen; Liang, Jian-Jong; Liao, Chun-Che ; Lin, Yi-Ling ; Yuan, Hanna S. ; Lim, Carmay Chemical Science 12(17), 6210
32021Correction to “Synergistic Inhibition of SARS-CoV-2 Replication Using Disulfiram/Ebselen and Remdesivir”Chen, T; Fei, CY; Chen, YP; Sargsyan, K; Liang, JJ; Liao, CC ; Lin, YL ; Chang, CP; Yuan, HS ; Lim, C ACS pharmacology & translational science 4(3), 1246
42012Crystal structure of human polynucleotide phosphorylase: Insights into its domain function in RNA binding and degradationLin, C. L.; Hsiao, Y. -Y.; Wang, Y. -T; Yang, W. -Z.; Yuan, H. S. Nucleic Acids Res. 40(9), 4146-4157
52012How an exonuclease decides where to stop in trimming of nucleic acids: crystal structures of RNase T-product complexesHsiao, Y. -Y.; Duh, Y.; Chen, Y. -P.; Wang, Y. -T.; Yuan, H. S. Nucleic Acids Res 40, 8144-8154
62012Recombination in the non-structural gene region in type-2 dengue virusesSu, M. W.; Yuan, H. S. ; Chu, W. C.Intervirology 55(3), 225-230
72012Structural insights into DNA binding and cleavage by CPS-6 from Caenorhabditis elegansLin, J. L. J.; Lin, C. L.; Hsiao, Y. Y.; Doudeva, L. G.; Yang, W. -Z.; Wang, Y. -T.; Yuan, H. S. Journal of Biological Chemistry 287, 7110-7120
82011Structural basis for RNA trimming by RNase T in stable RNA 3'-end maturationHsiao, Y. -Y.; Yang, C. -C; Lin, C. L.; Lin, J. L. J.; Duh, Y.; Yuan, H. S. Nature Chemical Biology 7(4), 236-243
92010Structural and biochemical characterization of CRN-5 and Rrp46: an exosome component participating in apoptotic DNA degradationYang, C. -C; Wang, Y. -T.; Hsiao, Y. Y.; Doudeva, L. G.; Kuo, P. -H.; Chow, S. Y.; Yuan, H. S. RNA 16, 1748-1759
102009Categorizing host-dependent RNA viruses by principal component analysis of their codon usage preferencesSu, M. -W.; Lin, H. -M.; Yuan, H. S. ; Chu, W. -C.Journal of Computational Biology 16, 1539-1547
112009Redesign of high-affinity nonspecific nucleases with altered sequence preferenceWang, Y. -T.; Wright, J. D.; Doudeva, L. G.; Chen, H. -C.; Lim, C.; Yuan, H. S. J Am Chem Soc 131, 17345-17353
122009Structural insights into TDP-43 in nucleic-acid binding and domain interactionsKuo, P H; Doudeva, L. G.; Wang, Y. -T.; Shen, C. -K. J. ; Yuan, H. S. Nucleic Acids Research 37(6), 1799-1808
132009Structural and catalytic roles of residues located in beta13 strand and the following beta-turn loop in Fibrobacter succinogenes 1,3-1,4-beta-D-glucanaseLin, Y. S.; Tsai, L. C.; Lee, S. H.; Yuan, H. S. ; Shyur, L. F.Biochimica et Biophysica Acta-General Subjects 1790, 231-239
142009Crystal structure of CRN-4: implications for domain function in apoptotic DNA degradationHsiao, Y. Y.; Nakagawa, A.; Shi, Z.; Mitani, S.; Xue, D.; Yuan, H. S. Mol Cell Biol 29, 448-457
152008Crystal structure of Escherichia coli PNPase: central channel residues are involved in processive RNA degradation.Shi, Z.; Yang, W. -Z.; Lin-Chao, S. ; Chak, K. -F.; Yuan, H. S RNA 14, 2361-2371
162008Structural and functional insights into human Tudor-SN, a key component linking RNA interference and editingLi, C. L.; Yang, W. Z.; Chen, Y. P.; Yuan, H. S. Nucleic Acids Research 36, 3579-3589
172007The Conserved Asparagine in the HNH Motif Serves an Important Structural Role in Metal Finger EndonucleasesHuang, H.; Yuan, H. S. Journal of Molecular Biology 368(3), 812-821
182007Structural basis for sequence-dependent DNA cleavage by nonspecific endonucleasesWang, Y. T.; Yang, W. J.; Li, C. L.; Doudeva, L. C.; Yuan, H. S. Nucleic Acids Research 35, 584-594
192007Inhibition of IS2 transposition by factor for inversion stimulationLei, G. S.; Chen, C. J.; Yuan, H. S. ; Wang, S. H.; Hu, S. T.FEMS Microbiol Lett 275, 98-105
202006Crystal structural analysis and metal-dependent stability and activity studies of the ColE7 endonuclease domain in complex with DNA/Zn2+ or inhibitor/Ni2+Doudeva, L. G.; Huang, H.; Hsia, K. C.; Shi, Z.; Li, C. L.; Shen, Y.; Yuan, H. S. Protein Sci 15, 269-280
212006High-resolution crystal structure of a truncated ColE7 translocation domain: implications for colicin transport across membranesCheng, Y. S.; Shi, Z.; Doudeva, L. G.; Yang, W. Z.; Chak, K. F.; Yuan, H. S. J Mol Biol 356, 22-31
222006The critical roles of polyamines in regulating ColE7 production and restricting ColE7 uptake of the colicin producing Escherichia coliPan, YH; Liao, CC; Kuo, CC; Duan, KJ; Liang, PH ; Yuan, HS ; Hu, ST; Chak, KFJournal of Biological Chemistry 281(19), 13083-13091
232005Stabilization and enhancement of the antiapoptotic activity of mcl-1 by TCTPLiu, H.; Peng, H. W.; Cheng, Y. S.; Yuan, H. S. ; Yang-Yen, H. F. Molecular and Cellular Biology 25(8), 3117-3126
242005Identification of an essential cleavage site in ColE7 required for importand killing of cellsShi, Z.; Chak, K. F.; Yuan, H. S. J Biol Chem 280, 24663-24668
252005Structural and functional insight into sugar-nonspecific nucleases in host defenseHsia, K. C.; Li, C. L.; Yuan, H. S. Curr Opin Struct Biol 15, 126-134
262004DNA Binding and Degradation by the HNH Protein ColE7Hsia, K. C.; Chak, K. F.; Liang, P. H. ; Cheng, Y. S.; Ku, W. Y.; Yuan, H. S. Structure 12(2), 205-214
272004Involvement of colicin in the limited protection of the colicin producing cells against bacteriophageLin, YH; Liao, CC; Liang, PH ; Yuan, HS ; Chak, KFBiochemical and Biophysical Research Communications 318(1), 81-87
282003Crystal structure of a natural circularly permuted jellyroll protein: 1,3-1,4-beta-D-glucanase from Fibrobacter succinogenesTsai, L. C.; Shyur, L. F.; Lee, S. H.; Lin, S. S.; Yuan, H. S. J Mol Biol 330, 607-620
292003DNA binding and cleavage by the periplasmic nuclease Vvn: a novel structure with a known active siteLi, C. L.; Hor, L. I.; Chang, Z. F.; Tsai, L. C.; Yang, W. Z.; Yuan, H. S. EMBO J 22, 4014-4025
302002The crystal structure of the nuclease domain of colicin E7 suggests a mechanism for binding to double-stranded DNA by the H-N-H endonucleasesCheng, Y. S.; Hsia, K. C.; Doudeva, L. G.; Chak, K. F.; Yuan, H. S. J Mol Biol 324, 227-236
312002Characterization of the specific cleavage of ceiE7-mRNA of the bactericidal ColE7 operonChang, S. J.; Hsieh, S. Y.; Yuan, H. S. ; Chak, K. F.Biochem Biophys Res Commun 299, 613-620
322002Metal ions and phosphate binding in the H-N-H motif: crystal structures of the nuclease domain of ColE7/Im7 in complex with a phosphate ion and different divalent metal ionsSui, M. J.; Tsai, L. C.; Hsia, K. C.; Doudeva, L. G.; Ku, W. Y.; Han, G. W.; Yuan, H. S. Protein Sci 11, 2947-2957
332002Mutagenesis of Trp(54) and Trp(203) residues on Fibrobacter succinogenes 1,3-1,4-beta-D-glucanase significantly affects catalytic activities of the enzymeCheng, H. L.; Tsai, L. C.; Lin, S. S.; Yuan, H. S. ; Yang, N. S.; Lee, S. H.; Shyur, L. F.Biochemistry 41, 8759-8766
342002Structural studies of the pigeon cytosolic NADP(+)-dependent malic enzymeYang, Z.; Zhang, H.; Hung, H. C.; Kuo, C. C.; Tsai, L. C.; Yuan, H. S. ; Chou, W. Y.; Chang, G. G.; Tong, L.Protein Sci 11, 332-341
352002The zinc ion in the HNH motif of the endonuclease domain of colicin E7 is not required for DNA binding but is essential for DNA hydrolysisKu, WY; Liu, YW; Hsu, YC; Liao, CC; Liang, PH ; Yuan, HS ; Chak, KFNucleic Acids Research 30(7), 1670-1678
362001Processing of DNase domain during translocation of colicin E7 across the membrane of Escherichia coliLiao, CC; Hsiao, KC; Liu, YW; Leng, PH ; Yuen, HS ; Chak, KFBiochemical and Biophysical Research Communications 284(3), 556-562
372001Directed Mutagenesis of Specific Active Site Residues onFibrobacter succinogenes1,3–1,4-β-d-Glucanase Significantly Affects Catalysis and Enzyme Structural StabilityChen, JL; Tsai, LC; Wen, TN ; Tang, JB; Yuan, HS ; Shyur, LF Journal of Biological Chemistry 276(21), 17895-17901
382001Crystallization and preliminary X-ray diffraction analysis of the 1,3-1,4-beta-D-glucanase from Fibrobacter succinogenesTsai, L. C.; Shyur, L. F.; Lin, S. S.; Yuan, H. S. Acta Crystallographica Section D-Biological Crystallography 57, 1303-1306
392001Structural basis of non-specific lipid binding in maize lipid-transfer protein complexes revealed by high-resolution X-ray crystallographyHan, G. W.; Lee, J. Y.; Song, H. K.; Chang, C.; Min, K.; Moon, J.; Shin, D. H.; Kopka, M. L.; Sawaya, M. R.; Yuan, H. S. ; Kim, T. D.; Choe, J.; Lim, D.; Moon, H. J.; Suh, S. W.J Mol Biol 308, 263-278
402000Structural analysis of the transcriptional activation on Fis: crystal structures of six Fis mutants with different activation propertiesCheng, Y. S.; Yang, W. Z.; Johnson, R. C.; Yuan, H. S. J Mol Biol 302, 1139-1151
411999The crystal structure of the DNase domain of colicin E7 in complex with its inhibitor Im7 proteinKo, T. P.; Liao, C. C.; Ku, W. Y.; Chak, K. F.; Yuan, H. S. Structure 15, 91-102
421999Crystallization and preliminary crystallographic analysis of the Escherichia coli tyrosine aminotransferaseKo, T. P.; Wu, S. P.; Yang, W. Z.; Tsai, H.; Yuan, H. S. Acta Crystallographica Section D-Biological Crystallography 55, 1474-1477
431999Crystallization and preliminary x-ray diffraction analysis of malic enzyme from pigeon liverTsai, L. C.; Kuo, C. C.; Chou, W. Y.; Chang, G. G.; Yuan, H. S. Acta Crystallographica Section D-Biological Crystallography 55, 1930-1932
441999Expression, crystallization and preliminary x-ray diffraction studies of N-carbamyl-D-amino-acid amidohydrolase from Agrobacterium radiobacterHsu, W. H.; Chien, F. T.; Hsu, C. L.; Wang, T. C.; Yuan, H. S. ; Wang, W. C.Acta Crystallographica Section D-Biological Crystallography 55, 694-695
451999Hierarchical order of critical residues on the immunity-determining region of the Im7 protein which confer specific immunity to its cognate colicinLu, F. M.; Yuan, H. S. ; Hsu, Y. C.; Chang, S. J.; Chak, K. F.Biochem Biophys Res Commun 264, 69-75
461999Quantitative phase determination for macromolecular crystals using stereoscopic multibeam imagingChang, S. L.; Chao, C. H.; Huang, Y. S.; Jean, Y. C.; Sheu, H. S.; Liang, F. J.; Chien, H. C.; Chen, C. K.; Yuan, H. S. Acta Crystallogr A 55, 933-938
471998Conversion of a beta-strand to an alpha-helix induced by a single-site mutation observed in the crystal structure of Fis mutant Pro26AlaYang, W. Z.; Ko, T. P.; Corselli, L.; Johnson, R. C.; Yuan, H. S. Protein Sci 7, 1875-1883
481997The transactivation region of the fis protein that controls site-specific DNA inversion contains extended mobile beta-hairpin armsSafo, M. K.; Yang, W. Z.; Corselli, L.; Cramton, S. E.; Yuan, H. S. ; Johnson, R. C.EMBO J 16, 6860-6873
491997A novel role of ImmE7 in the autoregulatory expression of the ColE7 operon and identification of possible RNase active sites in the crystal structure of dimeric ImmE7Hsieh, S. Y.; Ko, T. P.; Tseng, M. Y.; Ku, W.; Chak, K. F.; Yuan, H. S. EMBO J. 16, 1444-1454
501996The crystal structure of the immunity protein of colicin E7 suggests a possible colicin-interacting surfaceChak, K. F.; Safo, M. K.; Ku, W. Y.; Hsieh, S. Y.; Yuan, H. S. Proceedings of the National Academy of Sciences of the United States of America 93, 6437-6442
511995Crystallization and preliminary X-ray crystallographic analysis of ImmE7 protein of colicin E7Ku, W. Y.; Wang, C. S.; Chen, C. Y.; Chak, K. F.; Safo, M. K.; Yuan, H. S. Proteins 23, 588-590
521994The structure of Fis mutant Pro61Ala illustrates that the kink within the long alpha-helix is not due to the presence of the proline residueYuan, H. S. ; Wang, S. S.; Yang, W. Z.; Finkel, S. E.; Johnson, R. C.J Biol Chem 269, 28947-28954
531994Determination of the absolute configuration of (S)-(+)-neopentyl-1-d alcohol by neutron diffraction study of strychnium neopentylphthalateYuan, H. S. ; Stevens, R. C.; Bau, R.; Mosher, H. S.; Koetzle, T. F.Proceedings of the National Academy of Sciences of the United States of America 91, 12872-12876