Issue Date | Title | Author(s) | Relation | scopus | WOS | Fulltext/Archive link |
2011 | A humanized immunoenzyme with enhanced activity for glucuronide prodrug activation in the tumor microenvironment. | Chen, KC; Wu, SY; Leu, YL; Prijovich, ZM; Chen, BM; Wang, HE; Cheng, TL; Roffler, SR | Bioconjugate chemistry 22(5), 938-948 | | | |
2012 | An activity-based near-infrared glucuronide trapping probe for imaging beta-glucuronidase expression in deep tissues. | Cheng, TC; Roffler, SR; Tzou, SC; Chuang, KH; Su, YC; Chuang, CH; Kao, CH; Chen, CS; Harn, IH; Liu, KY; Cheng, TL; Leu, YL | Journal of the American Chemical Society 134(6), 3103-3110 | | | |
2009 | Antiangiogenesis targeting tumor microenvironment synergizes glucuronide prodrug antitumor activity. | Juan, TY; Roffler, SR; Hou, HS; Huang, SM; Chen, KC; Leu, YL; Prijovich, ZM; Yu, CP; Wu, CC; Sun, GH; Cha, TL | CLINICAL CANCER RESEARCH 15(14), 4600-4611 | | | |
2008 | Directed evolution of a lysosomal enzyme with enhanced activity at neutral pH by mammalian cell-surface display. | Chen, KC; Wu, CH; Chang, CY; Lu, WC; Tseng, Q; Prijovich, ZM; Schechinger, W; Liaw, YC ; Leu, YL; Roffler, SR | Chemistry & Biology 15(12), 1277-1286 | | | |
2015 | Discovery of Specific Inhibitors for Intestinal E. coli beta-Glucuronidase through In Silico Virtual Screening. | Cheng, TC; Chuang, KH; Roffler, SR; Cheng, KW; Leu, YL; Chuang, CH; Huang, CC; Kao, CH; Hsieh, YC; Chang, LS; Cheng, TL; Chen, CS | TheScientificWorldJournal 2015, 740815 | | | |
2012 | ECSTASY, an adjustable membrane-tethered/soluble protein expression system for the directed evolution of mammalian proteins. | Chen, CP; Hsieh, YT; Prijovich, ZM; Chuang, HY; Chen, KC; Lu, WC; Tseng, Q; Leu, YL; Cheng, TL; Roffler, SR | PROTEIN ENGINEERING DESIGN & SELECTION 25(7), 367-375 | | | |
2011 | Enhancement of CPT-11 antitumor activity by adenovirus-mediated expression of beta-glucuronidase in tumors. | Huang, PT; Chen, KC; Prijovich, ZM; Cheng, TL; Leu, YL; Roffler, SR | Cancer gene therapy 18(6), 381-389 | | | |
2022 | Inhibition of gut microbial β-glucuronidase effectively prevents carcinogen-induced microbial dysbiosis and intestinal tumorigenesis | Cheng, KW; Tseng, CH; Chen, IJ; Huang, BC; Liu, HJ; Ho, KW; Lin, WW; Chuang, CH; Huang, MY; Leu, YL; Roffler, SR ; Wang, JY; Chen, YL; Cheng, TL | Pharmacological research 177, 106115 | | | |
2014 | PET Imaging of beta-Glucuronidase Activity by an Activity-Based 124I-Trapping Probe for the Personalized Glucuronide Prodrug Targeted Therapy. | Su, YC; Cheng, TC; Leu, YL; Roffler, SR; Wang, JY; Chuang, CH; Kao, CH; Chen, KC; Wang, HE; Cheng, TL | Molecular Cancer Therapeutics 13(12), 2852-2863 | | | |
2016 | Synthesis and Antitumor Properties of BQC-Glucuronide, a Camptothecin Prodrug for Selective Tumor Activation. | Prijovich, ZM; Burnouf, PA; Chou, HC; Huang, PT; Chen, KC; Cheng, TL; Leu, YL; Roffler, SR | Molecular pharmaceutics 13(4), 1242-50 | | | |
2013 | The anaerobic and aerobic cleavage of the steroid core ring structure by Steroidobacter denitrificans. | Wang, PH; Leu, YL; Ismail, W; Tang, SL; Tsai, CY; Chen, HJ; Kao, AT; Chiang, YR | JOURNAL OF LIPID RESEARCH 54:1493-1504 | | | |